Technical note: standardized and semiautomated Harris lines detection

American Journal of Physical Anthropology
Susanne K SuterFrank J Rühli

Abstract

Arrest in long bone growth and the subsequent resumption of growth may be visible as radiopaque transverse lines in radiographs (Harris lines, HL; Harris, HA. 1933. Bone growth in health and disease. London: Oxford University Press). The assessment of individual age at occurrence of such lines, as part of paleopathological skeletal studies, is time-consuming and shows large intra- and interobserver variability. Thus, a standardized, automated detection algorithm would help to increase the validity of such paleopathological research. We present an image analysis application facilitating automatic detection of HL. On the basis of established age calculation methods, the individual age-at-formation can be automatically assessed with the tool presented. Additional user input to confirm the automatic result is possible via an intuitive graphical user interface. Automated detection of HL from digital radiographs of a sample of late Medieval Swiss tibiae was compared to the consensus of manual assessment by two blinded expert observers. The intra- and interobserver variability was high. The quality of the observer result improved when standardized detection criteria were defined and applied. The newly developed algorithm detected two-...Continue Reading

References

May 1, 1976·American Journal of Physical Anthropology·H M McHenry, P D Schulz
Jul 1, 1991·American Journal of Physical Anthropology·S Byers
Mar 1, 1985·American Journal of Physical Anthropology·J R Hummert, D P Van Gerven
May 1, 1974·American Journal of Physical Anthropology·M J AllisonA Pezzia
Jul 1, 1968·American Journal of Physical Anthropology·H McHenry
Jul 1, 1969·American Journal of Physical Anthropology·P S Gindhart
Mar 1, 1984·American Journal of Physical Anthropology·G J Maat
Sep 1, 1994·American Journal of Physical Anthropology·R MacchiarelliA Sperduti
Jun 1, 1997·American Journal of Physical Anthropology·J L Grolleau-RaouxS R Saunders
Jan 6, 1999·Archives of Disease in Childhood·V V KhadilkarR Stanhope
Oct 5, 2007·Alcohol·Emilio González-ReimersMelchor Rodríguez Gaspar

❮ Previous
Next ❯

Citations

Mar 10, 2011·American Journal of Human Biology : the Official Journal of the Human Biology Council·Christina PapageorgopoulouFrank Siegmund
Oct 11, 2014·American Journal of Physical Anthropology·Amy B Scott, Robert D Hoppa
May 6, 2016·Pediatric Radiology·Matthew A ZapalaPaul K Kleinman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.