Technique and outcome of autotransplanting thyroid tissue after total thyroidectomy for simple multinodular goiters

Asian Journal of Surgery
Amr A MohsenArsany T Wassef

Abstract

Limited animal and human studies have shown function, albeit inadequate, of implanted thyroid tissue in muscles. This work aimed to ascertain results in a larger number of patients, finding practical method for implantation, studying the effect of changing weight of implant and effect of passage of time on its function. Forty patients had total thyroidectomy for simple multinodular goiters. A piece of the excised gland was finely minced, mixed with saline as emulsion, and injected in thigh muscles. Twelve patients had 5-g implants, while 28 patients had 10-g implants. Four parameters were studied at 2 months, 6 months, and 12 months: technetium isotope uptake by the implant; thyroid stimulating hormone (TSH); free T3 (FT3); and free T4 (FT4). All autotransplanted thyroid tissue survived and functioned. After 12 months, mean values (± standard deviation) of isotope uptake, TSH, FT3, and FT4 of the 5-g implants were 0.44 ± 0.16%, 27.74 ± 30.4 UI/mL, 3.07 ± 1.10 pg/mL, and 1.01 ± 0.3 ng/dL, repectively. Those for the 10 g implants were 0.71 ± 0.20%, 22.78 ± 19.7 UI/mL, 3.92 ± 1.2 pg/mL, and 1.05 ± 0.3 ng/dL, repectively. Ten-gram implants showed significantly higher isotope uptake than 5-g. TSH, FT3, and FT4 significantly improved...Continue Reading

Associated Clinical Trials

Dec 28, 2020·Mohamed Ahmed Hassan Aly

References

Apr 1, 1991·European Journal of Pediatrics·J P ChanoineF Delange
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Jul 29, 2003·Surgery Today·Pankaj Gupta RoyRajan Sankar
Oct 1, 2011·Journal of Thyroid Research·Mohamed YousefKhaled Eltom

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Citations

May 24, 2017·Clinical and Experimental Otorhinolaryngology·Mahmoud Sakr, Ahmed Mahmoud
Jun 20, 2020·Clinical Nuclear Medicine·Shanmuga Sundaram Palaniswamy, Padma Subramanyam
Oct 28, 2017·Head & Neck·Mahmoud SakrIbrahim Fathi

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