Technique, safety, and feasibility of EUS-guided radiofrequency ablation in unresectable pancreatic cancer

Surgical Endoscopy
Filippo ScopellitiRoberto Girelli

Abstract

Radiofrequency ablation (RFA) is a well-recognized local ablative technique applied in the treatment of different solid tumors. Intraoperative RFA has been used for non-metastatic unresectable pancreatic ductal adenocarcinoma (PDAC), showing increased overall survival in retrospective studies. A novel RFA probe has recently been developed, allowing RFA under endoscopic ultrasound (EUS) guidance. Aim of the present study was to assess the feasibility and safety of EUS-guided RFA for unresectable PDACs. Patients with unresectable non-metastatic PDAC were included in the study following neoadjuvant chemotherapy. EUS-guided RFA was performed using a novel monopolar 18-gauge electrode with a sharp conical 1 cm tip for energy delivery. Pre- and post-procedural clinical and radiological data were prospectively collected. Ten consecutive patients with unresectable PDAC were enrolled. The procedure was successful in all cases and no major adverse events were observed. A delineated hypodense ablated area within the tumor was observed at the 30-day CT scan in all cases. EUS-guided RFA is a feasible and safe minimally invasive procedure for patients with unresectable PDAC. Further studies are warranted to demonstrate the impact of EUS-guid...Continue Reading

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Citations

Jan 23, 2019·Clinical Endoscopy·Zaheer Nabi, D Nageshwar Reddy
Jun 3, 2020·Journal of Clinical Gastroenterology·Giuseppe VanellaPaolo G Arcidiacono
Aug 17, 2019·Endoscopic Ultrasound·Barbara BradenChristoph Frank Dietrich
Sep 14, 2018·Current Treatment Options in Gastroenterology·Jonathan M Wyse, Anand V Sahai
Oct 6, 2020·Endoscopy International Open·Amaninder DhaliwalDouglas G Adler
May 1, 2020·Current Gastroenterology Reports·Irina M CazacuManoop S Bhutani
Oct 8, 2020·Clinical Endoscopy·Jun Seong HwangTae Jun Song
Sep 21, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·John M DeWittUNKNOWN AGA Center for GI Innovation and Technology
Mar 2, 2021·Frontiers in Medicine·Muhammad Nadeem YousafFizah S Chaudhary
Feb 21, 2021·Seminars in Oncology·Alberto LarghiGiampaolo Tortora
Jul 4, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Isabella FrigerioRoberto Girelli
May 27, 2020·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·R V FlakLars J Petersen

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