Techniques: species' finest blend--humanized mouse models in inflammatory skin disease research

Trends in Pharmacological Sciences
Frederik H IgneyThomas M Zollner

Abstract

Differences between humans and mice often hamper the transfer of promising results from the bench to the clinic. For ethical reasons, research that involves patients is limited, and so there is an urgent need for models that mimic the human situation as closely as possible. In recent years, there has been considerable progress in generating humanized mouse models, and their application to drug discovery has proved fruitful. So, how can mice be humanized, and how can humanized mice be employed in immunology research and drug discovery? In this article, we answer these questions, focusing on T-cell-mediated skin diseases as an example.

References

Feb 1, 1994·The Journal of Clinical Investigation·H L SpiegelbergA H Lucas
Feb 29, 1996·Nature·W H BoehnckeR Kaufmann
Dec 24, 1997·The Journal of Investigative Dermatology·N Rosenblatt-VelinC Hauser
Feb 14, 1998·The Journal of Clinical Investigation·A GilharR S Kalish
Apr 9, 1999·Archives of Dermatological Research·W H BoehnckeR Kaufmann
Jul 8, 1999·The American Journal of Pathology·B J Nickoloff, T Wrone-Smith
Sep 11, 1999·Archives of Dermatological Research·W H Boehncke
Mar 6, 2002·The Journal of Clinical Investigation·Thomas M ZollnerWolf-Henning Boehncke
Oct 30, 2003·The Journal of Investigative Dermatology. Symposium Proceedings·Richard S Kalish, Amos Gilhar
Nov 18, 2003·The Journal of Clinical Investigation·Louise S VilladsenJan G J van de Winkel
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeffrey S SchechnerJordan S Pober
Jan 8, 2004·The Journal of Investigative Dermatology·Michael P SchönW Henning Boehncke
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy C Kirkiles-SmithJordan S Pober
Mar 10, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·U HerzH Renz

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Citations

Oct 7, 2011·Biopreservation and Biobanking·Durdana GrossKhusru Asadullah
Jun 1, 2006·Expert Opinion on Drug Discovery·Frederik H IgneyThomas M Zollner
Jan 6, 2009·Annals of the New York Academy of Sciences·Marie KingDale L Greiner
Apr 19, 2016·Expert Opinion on Therapeutic Targets·Pietro SantulliFrédéric Batteux
Jul 15, 2015·Reproductive Sciences·Mahaut LeconteFrédéric Batteux

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