Technological advances in blood rheology

Critical Reviews in Clinical Laboratory Sciences
J Stuart, G B Nash

Abstract

The science of blood rheology (study of the flow and deformability of blood) is of increasing practical importance to the investigation of blood disorders. In diagnostic laboratories, rheological tests such as the erythrocyte sedimentation rate, zeta sedimentation ratio, and plasma viscosity are used to monitor patients with an acute-phase response of greater than 24 h duration. In sickle-cell anemia, new methods for measuring erythrocyte deformability can be used to investigate the pathogenesis of vaso-occlusion, to test potential anti-sickling drugs, and to monitor drug efficacy in clinical trials. Genetic defects in the structure of the red cell membrane can have rheological consequences, monitoring of which may be useful for diagnosis. Rheological analysis of red cells infected by Plasmodium falciparum has indicated that their abnormal flow behavior may be an important pathological factor in malaria. Finally, the flow behavior of white blood cells, particularly neutrophils, is also important, as these cells, once activated, have the potential to occlude microvessels. The authors have reviewed the laboratory methodology and clinical applications that have led to recent advances in these aspects of blood rheology.

References

Jun 1, 1979·Infection and Immunity·H FadenP L Ogra
Apr 1, 1979·Biophysical Journal·R M HochmuthE A Evans
Jan 1, 1979·Annual Review of Biochemistry·J A Op den Kamp
Jan 1, 1979·British Journal of Haematology·S G RichardsonR M Wilcox
Sep 1, 1976·Journal of Clinical Pathology·H L ReidT L Dormandy
Oct 1, 1990·British Journal of Haematology·G B NashM E Reid
Aug 18, 1988·Biochimica Et Biophysica Acta·T TiffertV L Lew
Nov 1, 1988·Journal of Clinical Pathology·B M Cooke, J Stuart
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D K KaulR L Nagel
Apr 8, 1989·BMJ : British Medical Journal·G CiuffettiG D Lowe
Oct 21, 1989·Lancet·B S BullJ Stuart
Dec 1, 1989·British Journal of Haematology·M N JohnstonJ Stuart
Apr 1, 1989·Molecular and Biochemical Parasitology·K RangachariW B Gratzer
Mar 1, 1989·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C RemyM Decorps
May 1, 1989·The American Journal of Physiology·M D Herbst, J H Goldstein
Jul 1, 1989·Biophysical Chemistry·W S PriceB A Cornell
Oct 1, 1988·Mechanisms of Ageing and Development·D A RivichH J Cohen
Feb 11, 1989·The American Journal of Physiology·M Haas, J H Harrison
Mar 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J M Shabot
Mar 1, 1989·The American Journal of Physiology·R P HebbelW Foker
Feb 1, 1989·Clinical Science·T C FisherA C Fisher
Feb 1, 1988·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·J A EyreJ I Sinclair
Oct 1, 1987·Journal of Clinical Pathology·J StuartA J Keidan
Oct 1, 1988·British Journal of Haematology·G B NashJ A Dormandy
May 1, 1988·British Journal of Haematology·J Stuart, J C Ellory

❮ Previous
Next ❯

Citations

Mar 3, 2007·Progress in Cardiovascular Diseases·Demosthenes KatritsisVasilios Marmarelis
Feb 1, 1993·Annals of Medicine·T Somer, H J Meiselman
Feb 29, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Rui HongLee Josephson
Jan 3, 2021·Clinical Hemorheology and Microcirculation·Paulo L FarberAna S Silva-Herdade

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.