PMID: 33209099Nov 20, 2020Paper

Technologies for Reading, Writing & Editing Omes

Journal of Biomolecular Techniques : JBT
George Church

Abstract

To achieve exponential improvements in cost and quality of DNA reading and writing (R&W) up to 10 million-fold, we've introduced a series of NGS technologies (for example, fluorescent microscopy, nanopore and direct electronic measures). The next steps are extending these revolutions to other biomolecules and their functional impacts - reflected in ever increasing resolution in time and in spatial 3D structures (R&W). A key recurring concept (going far beyond 'parallelism') is 'molecular multiplexing' in which pools of hundreds to trillions of tagged molecular and cellular types are treated with the same effort as single unpooled reactions. Improvements in quality and resolution do not increase costs, indeed often reduce them. Applications include therapeutic editing, genetic matchmaking, synthetic organs, pan-virus resistance and in situ diagnostics. New approaches to protein design for novel sensors and delivery vehicles are emerging. Software and other interfaces with the public are key components of future revolutions.

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