Tectal gliomas: assessment of malignant progression, clinical management, and quality of life in a supposedly benign neoplasm

Neurosurgical Focus
Malte MohmeTobias Martens

Abstract

OBJECTIVE Tectal gliomas constitute a rare and inhomogeneous group of lesions with an uncertain clinical course. Because these supposedly benign tumors are frequently followed up by observation over many years, the authors undertook this analysis of their own case series in an effort to demonstrate that the clinical course is highly variable and that there is a potential for a progressive biology. METHODS Clinical data analysis of 23 cases of tectal glioma (involving 9 children and 14 adults) was performed retrospectively. Radiographic data were analyzed longitudinally and MR images were evaluated for tumor volume, contrast enhancement, and growth progression. Quality of life was assessed using the EORTC BN20 and C30 questionnaires during follow-up in a subgroup of patients. RESULTS The patients' mean age at diagnosis was 29.2 years. The main presenting symptom at diagnosis was hydrocephalus (80%). Six patients were treated by primary tumor resection (26.1%), 3 patients underwent biopsy followed by resection (13.1%), and 3 patients underwent biopsy only (13.1%). For additional treatment of hydrocephalus, 14 patients (60.9%) received shunts and/or endoscopic third ventriculostomy. Radiographic tumor progression was observed in 4...Continue Reading

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Citations

Feb 18, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Niket GandhiCarlos Torres
Sep 27, 2018·Acta Neuropathologica Communications·Anthony P Y LiuIbrahim Qaddoumi

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Methods Mentioned

BETA
Biopsy
biopsies

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SPSS
Excel
GraphPad Prism

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