Teenage pregnancy complicated by primary invasive ovarian cancer: association for oncologic outcome

Journal of Gynecologic Oncology
Erin A BlakeKoji Matsuo

Abstract

To examine survival of teenage women with pregnancies complicated by primary ovarian cancer. This is a secondary analysis of a previously organized systematic literature review of primary ovarian cancer diagnosed during pregnancy. Cases eligible for analysis were patients whose age at cancer diagnosis and survival outcome were known (n=201). Pregnancy and oncologic outcome were then examined based on patient age. These were comprised of 95 (47.3%) epithelial ovarian cancers (EOCs), 82 (40.8%) malignant germ cell tumors (MGCTs), and 24 (11.9%) sex-cord stromal tumors (SCSTs). Teenage pregnancy was seen in 21 (10%) cases, and was highest among the SCST group compared to the other cancer types (EOC, 1.1%; MGCT, 14.6%; and SCST, 29.2%, p<0.001). Live birth rates, neonatal weight, full term delivery rates, and Cesarean section rates were similar between the teenage group and the non-teenage group (all, p>0.05); however, teenage pregnancy was significantly associated with an increased risk of serious maternal/neonatal adverse events (50% vs. 22.7%, p=0.013). On univariable analysis, teenage pregnancy was significantly associated with decreased ovarian cancer-specific survival (5-year rate: age ≥30, 79.6%; age 20-29, 87.2%; and age <2...Continue Reading

References

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Citations

Dec 20, 2020·Cancers·Dominik Franciszek DłuskiBożena Leszczyńska-Gorzelak

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Methods Mentioned

BETA
Cesarean section

Software Mentioned

Statistical Package for Social Science software ( SPSS )

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