Tegaserod does not alter fasting or meal-induced biliary tract motility

The American Journal of Gastroenterology
Robert S FisherDavid L Earnest

Abstract

Tegaserod is a 5-HT(4) receptor partial agonist that increases peristaltic activity of the intestinal tract. It is approved for the treatment of patients with irritable bowel syndrome with constipation (IBS-C). IBS is a chronic gastrointestinal disorder of function that is reported to be associated with an increased incidence of abdominal surgery including cholecystectomy. The effect of tegaserod on nongut digestive organs, such as the gallbladder and biliary tract, has not been previously investigated. Therefore, this study aimed to evaluate the effects of tegaserod on gallbladder contractility and on functional status of the sphincter of Oddi during both the interdigestive and the digestive periods in healthy female subjects and in female patients with IBS-C. During a 6-wk, double-blind, placebo-controlled crossover study, gallbladder contractility and concomitant change in luminal diameter of the common hepatic duct (CHD) and the common bile duct (CBD, both proximal and distal) in response to a standard liquid meal were quantified using real-time ultrasonography. Changes in luminal diameter of the CHD and the CBD were used as a surrogate marker for sphincter of Oddi function. Ultrasound measurements were conducted every 15 m...Continue Reading

References

Jun 1, 1990·Digestive Diseases and Sciences·R A BakerJ Toouli
Jun 1, 1989·The Australian and New Zealand Journal of Surgery·J Toouli
Sep 1, 1989·The American Journal of Physiology·T PeetersG Vantrappen
Jan 1, 1986·European Journal of Clinical Pharmacology·L MarzioF Cuccurullo
Nov 1, 1985·AJR. American Journal of Roentgenology·W J DoddsM K Kern
Jan 1, 1980·British Journal of Pharmacology·S A Doggrell, G W Scott
Dec 1, 1993·Alimentary Pharmacology & Therapeutics·D J ZiegenhagenE Zehnter
Mar 1, 1996·Digestive Diseases and Sciences·R PatankarC D Johnson
Nov 14, 1998·The American Journal of Physiology·K Hillsley, G M Mawe
Jul 21, 2000·Alimentary Pharmacology & Therapeutics·K J van ErpecumG P Vanberge-Henegouwen
Dec 21, 2000·The British Journal of Surgery·T M Kennedy, R H Jones
May 9, 2001·Digestive Diseases and Sciences·R von KiedrowskiR Raedsch
Sep 25, 2002·Alimentary Pharmacology & Therapeutics·S SenguptaL J D O'Donnell
May 2, 2003·Journal of Clinical Pharmacology·Suzanne K SwanJames F McLeod
Sep 17, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L Marzio

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Citations

Mar 25, 2008·Therapeutics and Clinical Risk Management·Peter LayerAndreas Kreiss
Mar 1, 2006·Expert Opinion on Drug Safety·John McLaughlin, Lesley A Houghton
Sep 7, 2014·Digestive Diseases and Sciences·Klaus BielefeldtDhiraj Yadav

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