Tegumental surface changes in adult Fasciola hepatica in response to treatment in vivo with triclabendazole in the sheep host

Veterinary Parasitology
Emma TonerI Fairweather

Abstract

Eight indoor-reared crossbred sheep with no pre-exposure to Fasciola hepatica were infected by oral gavage with 200 metacercarial cysts of the triclabendazole (TCBZ)-susceptible Cullompton isolate of F. hepatica. At 12 weeks post-infection, sheep were dosed with 10mg/kg triclabendazole. Two sheep per time period were euthanized at 48h, 72h and 96h post-treatment. Two control sheep were euthanized alongside the 96h triclabendazole-treated sheep. Flukes were recovered from each of the sheeps' liver and, if present, from the gall bladder, and they were processed for scanning electron microscopy (SEM). Flukes recovered 48h post-treatment were active. Disruption to the tegument took the form of swelling, widespread blebbing and some loss of the tegument covering the spines. By 72h post-treatment, all flukes recovered were dead and a number were recovered from the gall bladder. Typically, the posterior end of the flukes was elongated and in this region the tegumental syncytium had sloughed away. Tegumental loss was more widespread on flukes recovered from the gall bladder. At 96h post-treatment, only one fluke was recovered from the liver and three from the gall bladder. All the flukes were dead and they were totally devoid of tegume...Continue Reading

References

Mar 1, 1987·Journal of Veterinary Pharmacology and Therapeutics·D R HennessyR K Prichard
Jan 14, 1984·The Veterinary Record·K TurnerR J Richards
Oct 25, 1980·The Veterinary Record·R A Chevis
Feb 13, 2001·Veterinary Parasitology·C P GaasenbeekF H Borgsteede
Apr 2, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L MottierC Lanusse
Sep 13, 2005·Journal of Helminthology·I Fairweather
May 4, 2006·Journal of Veterinary Pharmacology and Therapeutics·G VirkelC Lanusse
Nov 26, 2008·Veterinary Parasitology·L HalfertyI Fairweather
Jan 24, 2009·Journal of Veterinary Pharmacology and Therapeutics·G VirkelC Lanusse
Apr 16, 2009·Journal of Helminthology·I Fairweather
Apr 21, 2009·Veterinary Parasitology·Santiago Mas-ComaMaria Dolores Bargues

❮ Previous
Next ❯

Citations

Jan 14, 2011·Veterinary Parasitology·I Fairweather
Oct 11, 2016·Trends in Parasitology·Eduardo de la Torre-EscuderoMark W Robinson
Aug 24, 2010·Journal of Proteome Research·Gustavo ChemalePeter M Brophy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.