Mar 7, 2019

TEK is a novel prognostic marker for clear cell renal cell carcinoma

European Review for Medical and Pharmacological Sciences
Mihyang HaY H Kim

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. However, effective therapeutics for ccRCC are lacking. Novel biomarkers could provide critical information when determining prognoses for patients with ccRCC. In this study, we sought to determine if the expression of receptor tyrosine kinase (TEK) could be a potential novel prognostic biomarker for ccRCC. TEK, originally identified as an endothelial cell-specific receptor, plays an important role in the modulation of vasculogenesis and remodeling. Altered TEK expression has been observed in tumor tissues (e.g., oral squamous cell carcinomas, leukemia) and breast, gastric and thyroid cancers. However, the role of TEK in ccRCC remains unknown. Differential TEK expression between non-metastatic (stage M0) and metastatic (stage M1) ccRCC patient cohorts was determined from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC). Furthermore, TEK expression was assessed as a prognostic factor using the time-dependent area under the curve (AUC) of Uno's C-index, the AUC value of the receiver operating characteristics (ROC) at 5 years, Kaplan-Meier survival curves and multivariate analyses. A Kaplan-Meier curve analysis reve...Continue Reading

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Mentioned in this Paper

Biological Markers
Study
The Cancer Genome Atlas
Genome
Tumor Tissue Sample
Conventional (Clear Cell) Renal Cell Carcinoma
Non-Metastatic Neoplasm
Vasculogenesis
Activated protein C receptor
Receptor, TIE-2

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