TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma

Oncotarget
Yi SangTiebang Kang

Abstract

Metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). However, the molecular mechanisms of NPC metastasis are poorly understood. Here, using our customized gene microarray containing all of the known human transcription factors and the current markers for epithelial-mesenchymal transition, we report that TEL2 was down-regulated in highly metastatic NPC cells and the metastatic tissues in lymph node. Mechanistically, TEL2 inhibits the cell migration and invasion in vitro and metastasis in vivo by directly suppressing the SERPINE1 promoter in NPC. Consistently, an inverse correlation was observed between the protein levels of TEL2 and SERPINE1 using clinical NPC samples. Collectively, we have provided the first evidence that TEL2 plays a key role in NPC metastasis by directly down-regulating SERPINE1, and that this novel axis of TEL2 / SERPINE1 may be valuable to develop new strategies for treating NPC patients with metastasis.

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Citations

Dec 13, 2019·Oncotarget·Vasiliki SalametiFiona M Watt
Jan 24, 2020·Scientific Reports·José Luis Granados-SolerIngo Nolte
Nov 17, 2016·Proceedings of the National Academy of Sciences of the United States of America·Roberto RangelNeal G Copeland
Sep 27, 2018·Cancer Communications·Yi SangTiebang Kang
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Jun 29, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Minglei LiuWei Li
Jul 29, 2021·Cell Death & Disease·Laura PezzèYari Ciribilli
Jul 20, 2018·Neoplasia : an International Journal for Oncology Research·Federica AlessandriniYari Ciribilli

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Methods Mentioned

BETA
ChIP
ELISA
transfection
PCR
immunoprecipitation
Assay

Software Mentioned

SPSS

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