Telavancin for refractory methicillin-resistant Staphylococcus aureus bacteremia and infective endocarditis

Infectious Diseases
Michael A RuggeroJeffrey E Topal

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and infective endocarditis (IE) have become increasingly difficult to treat over the past decade, with suboptimal response rates of less than 50%. Although vancomycin and daptomycin are standard therapeutic options, treatment failures with either or both agents are common. Telavancin is a lipoglycopeptide antibiotic with activity against MRSA. In vitro, telavancin displays bactericidal activity and has lower minimum inhibitory concentrations to MRSA than vancomycin. We present a retrospective, case-series report of 14 patients treated with telavancin for refractory MRSA bacteremia with and without IE at our institution from 9 September 2010 to 2 April 2012. Of the 14 patients who received telavancin for refractory MRSA bacteremia and IE, eight survived their inpatient admission and were able to be followed for 30 days. The overall survival rate was 57% (n = 8). Of the eight surviving patients, five were diagnosed with MRSA IE and the remaining three were diagnosed with complicated MRSA bacteremia. All six patients who did not survive the inpatient admission were diagnosed with left-sided IE involving the mitral valves. This retrospective case series provides clinical...Continue Reading

References

Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J S LiG R Corey
Jan 17, 2002·The New England Journal of Medicine·E Mylonakis, S B Calderwood
Aug 18, 2006·The New England Journal of Medicine·Vance G FowlerUNKNOWN S. aureus Endocarditis and Bacteremia Study Group
Aug 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W Boucher, George Sakoulas
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alex SorianoJosep Mensa
May 1, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin E StryjewskiUNKNOWN Assessment of Telavancin in Complicated Skin and Skin-Structure Infections Study
May 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sara E Cosgrove, Vance G Fowler
Jul 22, 2009·Antimicrobial Agents and Chemotherapy·Klaudia Kosowska-ShickPeter C Appelbaum
Nov 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Louis D SaravolatzLeonard B Johnson
Feb 24, 2010·Antimicrobial Agents and Chemotherapy·Christopher S LundeBret M Benton
Jun 15, 2010·Diagnostic Microbiology and Infectious Disease·Elizabeth A NeunerPeggy S McKinnon
Sep 30, 2010·Antimicrobial Agents and Chemotherapy·Luis A Marcos, Bernard C Camins
Nov 17, 2010·Antimicrobial Agents and Chemotherapy·Alasdair P MacGowanKaren E Bowker
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ethan RubinsteinUNKNOWN ATTAIN Study Group
Feb 4, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S J van HalD L Paterson

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Citations

Nov 14, 2015·The Journal of Antimicrobial Chemotherapy·Ravina KullarSebastiaan J van Hal
Sep 1, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric Wenzler, Keith A Rodvold
May 22, 2016·Infectious Disease Clinics of North America·Marisa HolubarStan Deresinski
Dec 16, 2017·The Journal of Antimicrobial Chemotherapy·Nicholas S BrittGeorge Sakoulas
Nov 9, 2017·Expert Opinion on Pharmacotherapy·Carlota GudiolJordi Carratalà
Mar 23, 2017·Antimicrobial Agents and Chemotherapy·Truc T TranKavindra V Singh
Dec 30, 2016·Infection & chemotherapy·Eun Ju Choo, Henry F Chambers
Jul 14, 2018·Journal of Clinical Pharmacy and Therapeutics·Paul O LewisDavid B Cluck
Jul 5, 2018·JAMA : the Journal of the American Medical Association·Andrew WangVivian H Chu

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