Telbivudine Treatment during Late Pregnancy Prevents Mother-to-Child Transmission of Hepatitis B Virus: A Retrospective Study

Canadian Journal of Gastroenterology & Hepatology
Mengzhi CaiGang Qin

Abstract

To investigate the efficacy of telbivudine (LdT) in blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) during late pregnancy. A total of 651 pregnant women aged 18-40 in Nantong Third People's Hospital and Hospital affiliated to Nantong University with positive hepatitis B surface antigen (HBsAg) and HBV DNA were enrolled between January 2011 and December 2015. Patients with HBV DNA≥106 copies/mL (n=251) received LdT during late pregnancy according to the patients' will, while 136 high viral patients with HBV DNA≥106 copies/mL who did not take LdT therapy and 268 low viral patients with HBV DNA<106 copies/mL served as the controls. At 7 months and 1 year postpartum, the basal HBV DNA serum level of treated patients declined significantly (P<0.001), while no obvious decline was observed in the untreated high viraemic controls (P<0.05) and untreated low viraemic controls (P<0.05). Only 1 infant (0.4%) in LdT group was HBsAg positive at 7 months, while 14 (5.2%) were in the untreated low viraemic controls (P<0.001) and 15 (11.0%) were in untreated high viraemic controls (P<0.001). For pregnant women with HBV DNA≥106 copies/mL, the use of LdT during late pregnancy could effectively reduce the MTCT rate of HBV.

References

Dec 20, 2002·Pathologie-biologie·S Ranger-RogezF Denis
Oct 27, 2005·International Journal of Epidemiology·Susan T GoldsteinHarold S Margolis
Dec 21, 2007·The New England Journal of Medicine·Ching-Lung LaiUNKNOWN Globe Study Group
Jul 30, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Udayakumar NavaneethanMohamed T Shata
Jul 30, 2008·Gastroentérologie Clinique Et Biologique·Y Bacq
Feb 4, 2009·Best Practice & Research. Clinical Gastroenterology·Daniel Lavanchy
Feb 12, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Maureen M Jonas
Feb 22, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Calvin Q PanGen-Ju Wang
Apr 25, 2012·World Journal of Gastroenterology : WJG·Evangelista SagnelliPiero Luigi Almasio
Jun 27, 2014·International Journal of Women's Health·Ivan Gentile, Guglielmo Borgia
Jul 30, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Haruki KomatsuMitsuyoshi Suzuki
Aug 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu-Sheng WangHong-Yang Wang
Sep 18, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hua ZhangXin Liu
Nov 13, 2014·Canadian Journal of Gastroenterology & Hepatology·Julie van SchalkwykEric M Yoshida
Apr 9, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Huey-Ling ChenUNKNOWN Taiwan Study Group for the Prevention of Mother-to-Infant Transmission of HBV PreMIT Study
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Jan 8, 2016·Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology·UNKNOWN Chinese Society of Hepatology, Chinese Medical AssociationWei lai
Jun 16, 2016·The New England Journal of Medicine·Calvin Q PanUNKNOWN China Study Group for the Mother-to-Child Transmission of Hepatitis B
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultJohn B Wong
Feb 24, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hong-Lin ChenGang Qin
Mar 8, 2018·The New England Journal of Medicine·Gonzague JourdainNantasak Chotivanich
May 4, 2018·Canadian Journal of Gastroenterology & Hepatology·Hiroshi Miyata, Satoru Miyata

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enzyme-linked immunosorbent assay

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