Telemetry video-electroencephalography (EEG) in rats, dogs and non-human primates: methods in follow-up safety pharmacology seizure liability assessments

Journal of Pharmacological and Toxicological Methods
Leanne BassettS Authier

Abstract

Non-clinical seizure liability studies typically aim to: 1) confirm the nature of EEG activity during abnormal clinical signs, 2) identify premonitory clinical signs, 3) measure plasma levels at seizure onset, 4) demonstrate that drug-induced seizures are self-limiting, 5) confirm that conventional drugs (e.g. diazepam) can treat drug-induced seizures and 6) confirm the no observed adverse effect level (NOAEL) at EEG. Our aim was to originally characterize several of these items in a three species comparative study. Cynomolgus monkey, Beagle dog and Sprague-Dawley rat with EEG telemetry transmitters were used to obtain EEG using the 10-20 system. Pentylenetetrazol (PTZ) was used to determine seizure threshold or as a positive seizurogenic agent. Clinical signs were recorded and premonitory signs were evaluated. In complement, other pharmacological agents were used to illustrate various safety testing strategies. Intravenous PTZ doses required to induce clonic convulsions were 36.1 (3.8), 56.1 (12.7) and 49.4 (11.7) mg/kg, in Beagle dogs, cynomolgus monkeys and Sprague-Dawley rats, respectively. Premonitory clinical signs typically included decreased physical activity, enhanced physiological tremors, hypersalivation, ataxia, eme...Continue Reading

References

Sep 1, 1975·Neurology·P R Yarnell, N S Chu
Dec 1, 1992·Neurology·T S WalczakD V Lewis
Mar 12, 1998·The Journal of Small Animal Practice·A Jaggy, M Bernardini
Oct 12, 2000·Neuroscience Letters·M L JongsmaAnton M L Coenen
Mar 12, 2003·Pharmacotherapy·Kai Ming ChowPhilip Kam-Tao Li
May 2, 2003·IEEE Transactions on Bio-medical Engineering·Joël J NiederhauserBrian Litt
Dec 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Suzanne L HansenConnie Sánchez
Jun 3, 2004·Journal of Pharmacological and Toxicological Methods·Alan S BassPatricia Williams
Jun 8, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·David R Sargan
Jun 30, 2004·Neuropharmacology·Hester van LierAnton M L Coenen
Feb 18, 2005·Journal of Neurophysiology·Molly M SturmanDaniel M Corcos
Apr 23, 2005·The Journal of Comparative Neurology·Inmaculada Ballesteros YáñezJavier DeFelipe
Jun 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S J M Smith
Dec 14, 2005·Postgraduate Medical Journal·R Bhidayasiri
Jun 16, 2007·Seizure : the Journal of the British Epilepsy Association·Sanjay N MandhaneT Rajamannar
Jun 26, 2007·Journal of Pharmacological and Toxicological Methods·Niklaus DürmüllerPaul Moser
Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Josef G ThundiyilKent R Olson
Dec 2, 2008·Seizure : the Journal of the British Epilepsy Association·Alejandro ScaramelliBeatriz Arciere
Sep 16, 2009·Neurology·S R BenbadisNES Treatment Workshop
Jul 6, 2010·Journal of Pharmacological and Toxicological Methods·H J van der LindeD J Gallacher
Oct 13, 2010·Biochemical Pharmacology·Steven C LeiserDavid M Devilbiss
Jul 30, 2011·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·National Association of EMS Physicians

Citations

Mar 20, 2016·Journal of Pharmacological and Toxicological Methods·S AuthierCarrie Markgraf
Aug 27, 2015·Journal of Pharmacological and Toxicological Methods·Icilio Cavero, Henry Holzgrefe
Aug 17, 2014·Journal of Pharmacological and Toxicological Methods·M K PugsleyM J Curtis
Dec 4, 2014·Journal of Pharmacological and Toxicological Methods·M K PugsleyM J Curtis
Apr 30, 2016·Journal of Pharmacological and Toxicological Methods·S AuthierHolger Weis
Jun 7, 2016·Journal of Pharmacological and Toxicological Methods·S AuthierM J Curtis
Nov 30, 2019·Current Pharmaceutical Biotechnology·Takafumi Shirakawa, Ikuro Suzuki
Oct 5, 2020·Journal of Pharmacological and Toxicological Methods·Jamie K DaSilvaKatja Hempel
Oct 30, 2020·Drug Design, Development and Therapy·Yunlu LiuNa Yang

Related Concepts

Canis familiaris
Electroencephalogram
Intravenous Injections
Macaca fascicularis
Pentazol
Safety
Non-epileptic Convulsion
Telemetry
Rats, Holtzman
Amphetamine

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.