Teleocidin-induced modulation of growth and cell interaction in microenvironment-dependent mouse leukemias

Leukemia Research
H KaneshimaY Nishizuka

Abstract

Teleocidin is a new tumor-promoting substance chemically unrelated to phorbol groups. Its biological effects on thymic microenvironment-dependent leukemias derived from AKR spontaneous leukemias were studied in vitro in comparison with 12-O-tetradecanoylphorbol 13-acetate (TPA), a representative tumor promoter of the phorbol group. Teleocidin stimulated the in vitro growth of 21 out of 31 symbiotic cell lines in the absence of growth-supporting stromal cells. All the responders to teleocidin were responsive also to TPA and the degree of growth stimulation in each cell line was comparable. Both promoters could inhibit the symbiotic complex formation with thymic epithelial cells probably by affecting the cytoskeleton. All symbiotically cultured AKR leukemia cells expressed Thy-1.1 antigen, but their expression of Lyt-1.2 and Lyt-2.1 was heterogenous. There was no direct correlation between teleocidin-responsiveness and Lyt-phenotypes of the leukemia cells.

References

Dec 1, 1979·The Journal of Experimental Medicine·J Watson
Apr 1, 1978·The Journal of Experimental Medicine·B J MathiesonR Asofsky
Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H HiaiY Nishizuka
Jul 31, 1980·Biochemical and Biophysical Research Communications·H HoshinoT Sugimura
Aug 15, 1981·International Journal of Cancer. Journal International Du Cancer·H YamamotoT Sugimura
Feb 1, 1981·Cellular Immunology·J Fuller-FarrarJ J Farrar
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·H FujikiR E Moore
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·K Nagasawa, T W Mak
Jan 15, 1982·International Journal of Cancer. Journal International Du Cancer·D DeliaG Goldstein
Jan 1, 1980·Immunological Reviews·K A Smith

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Citations

Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F L OwenJ G Seidman
Oct 1, 1996·Pathology International·H Hiai

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