Teleost FTZ-F1 homolog and its splicing variant determine the expression of the salmon gonadotropin IIbeta subunit gene

Molecular Endocrinology
D LiuC L Hew

Abstract

Steroidogenic factor 1, a member of the fushi tarazu factor 1 (FTZ-F1) subfamily of nuclear receptors, is a key regulator in mammalian reproduction. From an embryonic complementary DNA library, the zebrafish homolog of FTZ-F1 (zFF1A) and an alternatively spliced variant (zFF1B) were isolated. zFF1B represented a C-terminally truncated version of zFF1A. Whole mount in situ hybridization and reverse transcriptase-PCR analysis revealed that both zFF1A and B transcripts were present in the developing pituitaries, adult fish brain, gonads, and liver, albeit zFF1B messenger RNA was absent in testis. Comparison of the primary sequences of zFF1 with those of other FTZ-F1 subfamily members showed a close structural relationship between the mouse liver receptor homolog, which activated the alpha1-fetoprotein gene in rodent liver. However, similar to mouse steroidogenic factor 1, zFF1A regulated chinook salmon gonadotropin IIbeta subunit gene expression. On the contrary, zFF1B, which could bind a consensus gonadotrope-specific element with an affinity similar to that of zFF1A, lacked both the trans-activation function and synergistic interaction with the estrogen receptor. Furthermore, cotransfection studies in HeLa cells showed that zFF1...Continue Reading

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Citations

Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M NittaB Shan
Sep 16, 2003·Molecular and Cellular Biology·Jean-Sébastien AnnicotteJohan Auwerx
Nov 12, 2005·Reproductive Biology and Endocrinology : RB&E·Jonas von Hofsten, Per-Erik Olsson
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Nov 9, 2002·European Journal of Biochemistry·Ricardo L De MendonçaRaymond J Pierce
Oct 28, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jarno KoskinenPer-Erik Olsson
Sep 16, 2008·General and Comparative Endocrinology·Sihui WangPhilippa Melamed
May 8, 2004·Trends in Cell Biology·Elisabeth FayardKristina Schoonjans
Apr 8, 2014·General and Comparative Endocrinology·Natàlia Garcia-ReyeroEdward J Perkins
Oct 26, 1999·Endocrine Reviews·V Giguère
Aug 19, 2000·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R MétivierF Pakdel

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