Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

Genes & Development
Hanno HockS H Orkin

Abstract

Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs.

References

Sep 8, 1995·Science·R KühnK Rajewsky
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S H CheshierI L Weissman
Mar 10, 2000·Science·T ChengD T Scadden
Mar 27, 2001·Nature Reviews. Genetics·S H Orkin
Mar 5, 2003·Annual Review of Immunology·Motonari KondoIrving L Weissman
Apr 30, 2003·Nature·Tannishtha ReyaIrving L Weissman
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J E Italiano, R A Shivdasani
Jan 14, 2004·The Journal of Experimental Medicine·Monica CobasFreddy Radtke

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Citations

Oct 25, 2011·Expert Reviews in Molecular Medicine·Qiang WenJohn D Crispino
Nov 16, 2013·Experimental & Molecular Medicine·Michael R Copley, Connie J Eaves
Oct 16, 2007·Oncogene·A N Goldfarb
Feb 9, 2010·The Journal of Biological Chemistry·Shuyang YuHai-Hui Xue
Jul 2, 2010·The Journal of Biological Chemistry·Jinzhong QinHanno Hock
Aug 30, 2008·The Journal of Experimental Medicine·Zhijian QianMichelle M Le Beau
Dec 14, 2011·The Journal of Experimental Medicine·Pieter Van VlierbergheAdolfo A Ferrando
Oct 16, 2007·Current Opinion in Hematology·Elisabeth M BattinelliJoseph E Italiano
Apr 17, 2008·Genes & Development·Tomomasa Yokomizo, Elaine Dzierzak
Feb 18, 2011·Genes & Development·Scott A Lacadie, Leonard I Zon
Sep 10, 2008·Molecular and Cellular Biology·Ryan J WozniakEmery H Bresnick
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Shenghui HeSean J Morrison
Sep 12, 2008·Annual Review of Pathology·Michael A Teitell, Pier Paolo Pandolfi
Dec 3, 2005·The Journal of Clinical Investigation·Liyan PangMortimer Poncz
Oct 2, 2012·The Journal of Clinical Investigation·Pieter Van Vlierberghe, Adolfo Ferrando
Sep 9, 2008·Cell Division·Carl R WalkleyStuart H Orkin
Mar 20, 2009·PLoS Biology·Amit J SabnisBenjamin S Braun
Nov 23, 2006·International Journal of Hematology·Yuka NakamuraKinuko Mitani
May 10, 2011·Annual Review of Biochemistry·Peter C HollenhorstBarbara J Graves
Jun 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Carl R Walkley, Stuart H Orkin
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ramiro GarzonCarlo M Croce
Jun 25, 2014·The Journal of Clinical Investigation·Monique F SmeetsCarl R Walkley
Apr 9, 2014·The Journal of Experimental Medicine·Adlen FoudiHanno Hock
Sep 1, 2012·Annual Review of Pathology·R Coleman Lindsley, Benjamin L Ebert
May 9, 2015·Clinical Genetics·A Savoia
Aug 17, 2011·Seminars in Diagnostic Pathology·Stefania PaoliniPier Paolo Piccaluga
Dec 16, 2010·Cancer Genetics and Cytogenetics·Hyojin ChaeSeok Lee

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