Telling the difference between frontotemporal dementia and Alzheimer's disease

Current Opinion in Psychiatry
Florence Pasquier

Abstract

A precise diagnosis of the cause of dementia during life is needed for proper management, in order to explain the symptoms to the patient and to the close relatives, and to give appropriate indications on the prognosis and possibly on the genetic risk. Frontotemporal dementia remains under-diagnosed and often misdiagnosed for Alzheimer's disease, the most common cause of dementia. More and more studies explore the differences between the two syndromes. Progress in neuropsychological testing improves the ability to distinguish between syndromes and knowledge on brain functioning. More attention has been paid over these last months--or years--on emotion, insight, behavior, artistic creativity and quality of responses. Yet, biomarkers do not improve the diagnostic accuracy of trained clinicians, and do not help to distinguish between histological subtypes of frontotemporal dementia. Improvement in knowledge on cognitive and emotional impairment in frontotemporal dementia and Alzheimer's disease is essential for the management of the patient--information can be given to the patients and the families that helps them to understand and to behave in consequence.

References

Jul 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·R BarberD Craufurd
Jan 1, 1997·European Neurology·F Pasquier, H Petit
Jun 18, 1999·Alzheimer Disease and Associated Disorders·I LavenuM Van der Linden
May 12, 2004·Neurology·D ChanM N Rossor
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Florence PasquierFlorence Lebert
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Andrew Kertesz, David Munoz
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Jennifer L WhitwellNick C Fox
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Harald Hampel, Stefan J Teipel
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Florence LebertFlorence Pasquier
Jun 24, 2004·Archives of Neurology·Bruce L Miller, Craig E Hou
Aug 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·J S SnowdenD M A Mann
Sep 24, 2004·Dementia and Geriatric Cognitive Disorders·I Lavenu, F Pasquier
Oct 21, 2004·Alzheimer Disease and Associated Disorders·UNKNOWN Alzheimer's Association
Oct 27, 2004·Neurology·K KantarciC R Jack
Nov 5, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z NedjamG Dalla Barba
Jan 7, 2005·Brain : a Journal of Neurology·Andrew GrahamJohn Hodges
Mar 12, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Katherine P RankinBruce L Miller
Mar 24, 2005·Annals of Neurology·David S KnopmanRonald C Petersen
Mar 24, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Mario F MendezBruce L Miller
Apr 5, 2005·Journal of Neuropathology and Experimental Neurology·Despina YancopoulouMaria Grazia Spillantini
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·K P RankinB L Miller
Apr 27, 2005·Journal of the Neurological Sciences·Jillian J KrilGlenda M Halliday
Apr 27, 2005·Neurology·W W SeeleyH J Rosen
Apr 27, 2005·Annals of Neurology·Murray GrossmanVirginia M-Y Lee
May 17, 2005·Journal of Neuropathology and Experimental Neurology·Ryan T MottChristine M Hulette
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·J C ThompsonD Neary
Jun 28, 2005·Dementia and Geriatric Cognitive Disorders·Mario F MendezBruce L Miller
Jul 13, 2005·Neuropsychologia·Diego Fernandez-Duque, Sandra E Black
Jul 13, 2005·Archives of Neurology·Rodney A ShortNeill R Graff-Radford

❮ Previous
Next ❯

Citations

Feb 16, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·O Turró-GarrigaR Sánchez-Valle
Feb 28, 2008·International Journal of Geriatric Psychiatry·Tor Atle RosnessKnut Engedal
May 27, 2014·Frontiers in Neurology·Pradeep Reddy RaamanaMirza Faisal Beg

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.