Telmisartan, a partial agonist of peroxisome proliferator-activated receptor gamma, improves impairment of spatial memory and hippocampal apoptosis in rats treated with repeated cerebral ischemia

Brain Research
Tamami HaraguchiMichihiro Fujiwara

Abstract

Telmisartan, an angiotensin type 1 receptor blocker (ARB), is used for hypertension to control blood pressure and has been shown to have a partial agonistic effect on peroxisome proliferator-activated receptor gamma (PPARgamma). Recently, the ligand of PPARgamma has been implicated in cerebroprotection due to its anti-inflammatory effect. In this study, we investigated whether telmisartan has a cerebroprotective effect on memory impairment and neuronal cell death induced by repeated cerebral ischemia. Repeated cerebral ischemia (RI: 10 min x 2) significantly induced impairment of spatial memory and hippocampal apoptosis in rats. Fourteen-day pre- and post-ischemic administration of telmisartan (0.3, 1, 3mg/kg/day, p.o.) increased the number of correct choices and reduced the number of errors made in the eight-arm radial maze task in a dose-dependent manner in RI treated rats. TUNEL-positive cells in the hippocampus CA1 areas were also reduced following 14-day administration of telmisartan (3mg/kg/day, p.o.). Seven-day post-ischemic administration of telmisartan improved spatial memory and reduced TUNEL-positive cells while 7-day pre-ischemic administration of telmisartan did not. These effects of telmisartan were inhibited by t...Continue Reading

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Citations

Aug 15, 2012·Psychopharmacology·Jan Józef BraszkoPiotr Jakubów
Jun 7, 2014·Pharmacological Reports : PR·Dominik Wincewicz, Jan J Braszko
Jun 21, 2012·Neurochemical Research·Chunhua ZhuXiaoyun Cao
Jul 30, 2014·The International Journal of Neuroscience·Tugba Nurcan YukselDeniz Unal
Jan 2, 2014·Oxidative Medicine and Cellular Longevity·Aurel Popa-WagnerAna-Maria Buga
Jan 18, 2014·Translational Stroke Research·Tomoko KurataKoji Abe
May 27, 2011·Journal of Pharmacological Sciences·Kotaro TakasakiKatsunori Iwasaki
Dec 17, 2014·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anjana BaliAmteshwar Singh Jaggi
Mar 16, 2018·International Journal of Molecular Sciences·LaDonya JacksonAdviye Ergul
Apr 2, 2017·Stroke; a Journal of Cerebral Circulation·Kouji WakayamaRyuichi Morishita
Jun 18, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Maha Mohammed Abdel-FattahAhmed Mohamed Mansour
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Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Muluken Altaye AyzaDerbew Fikadu Berhe
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Aug 2, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu YuanChunhui Li

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