Telmisartan Activates PPARδ to Improve Symptoms of Unpredictable Chronic Mild Stress-Induced Depression in Mice

Scientific Reports
Yingxiao LiHo-Shan Niu

Abstract

Major depression is a common mental disorder that has been established to be associated with a decrease in serotonin and/or serotonin transporters in the brain. Peroxisome proliferator-activated receptor δ (PPARδ) has been introduced as a potential target for depression treatment. Telmisartan was recently shown to activate PPARδ expression; therefore, the effectiveness of telmisartan in treating depression was investigated. In unpredictable chronic mild stress (UCMS) model, treatment with telmisartan for five weeks notably decrease in the time spent in the central and the reduced frequency of grooming and rearing in open filed test (OFT) and the decreased sucrose consumption in sucrose preference test (SPT) compared with the paradigms. Telmisartan also reversed the decrease in PPARδ and 5-HTT levels in the hippocampus of depression-like mice. Administration of PPARδ antagonist GSK0660 and direct infusion of sh-PPARδ into the brain blocked the effects of telmisartan on the improvement of depression-like behavior in these mice. Moreover, telmisartan enhanced the expression of PPARδ and 5HTT in H19-7 cells. In conclusion, the obtained results suggest that telmisartan improves symptoms of stress-induced depression in animals under ...Continue Reading

References

Jan 1, 1992·Neuroscience and Biobehavioral Reviews·R Muscat, P Willner
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·F K Stephan, I Zucker
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·D Lu, M K Raizada
Jan 1, 1996·Annual Review of Cell and Developmental Biology·T LembergerW Wahli
Dec 17, 2002·Journal of Psychiatric Research·David S JanowskyMichael Buyinza
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Mar 27, 2003·Journal of Cardiovascular Pharmacology·Jun Ming WangFrans H H Leenen
Sep 12, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrew HolmesDennis L Murphy
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Serge LuquetPaul A Grimaldi
Jul 28, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M-S KimK-U Lee
Oct 7, 2006·Journal of Psychiatric Research·Michael CollaIsabella Heuser
Apr 30, 2008·Biochemical and Biophysical Research Communications·Elizabeth E GirroirJeffrey M Peters
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaolong JiangHe Li
Jan 20, 2009·Biological Psychiatry·Andrew H MillerCharles L Raison
Apr 30, 2009·Annual Review of Neuroscience·Luke ClarkBarbara J Sahakian
Apr 15, 2010·Brain Research·Yukiko KasaharaTomohiro Matsuyama
Apr 20, 2010·Psychopharmacology·Natalia ElizaldeRosa M Tordera
Apr 27, 2011·Journal of Cellular Physiology·B D'AngeloA Cimini
Jul 30, 2011·British Journal of Pharmacology·A BrionesMj Ramírez
Jan 17, 2012·Journal of Affective Disorders·Brandon H Hidaka
May 15, 2012·Pharmacological Reports : PR·Luis H Llano LópezPascual A Gargiulo
Jun 21, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mathieu NolletSamuel Leman
Oct 11, 2012·North American Journal of Medical Sciences·Tahrin Mahmood, Ping-Chang Yang
May 29, 2013·Journal of Visualized Experiments : JoVE·Sarah L DeVos, Timothy M Miller
Jun 21, 2013·PloS One·Chin-Wei HuangSheng-Nan Wu
Jan 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Zhang TianzhuDu Juan
Sep 13, 2015·The International Journal of Neuropsychopharmacology·Miao-Jin JiHao Hong

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