Telmisartan Ameliorates Astroglial and Dopaminergic Functions in a Mouse Model of Chronic Parkinsonism

Neurotoxicity Research
Sathiya SekarSaravana Babu Chidambaram

Abstract

Many studies reported the neuroprotective effects of angiotensin II type 1 receptor (AT1R) antagonists in Parkinson's disease (PD). However, the role of AT1R blockade on astroglial, in turn, dopaminergic functions in chronic PD is still to be studied. In the present study, telmisartan (TEL; 3 and 10 mg/kg/day; p.o), was used to study the effects AT1R blockade on astrocytic and dopaminergic functions in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinsonism (250 mg/kg, i.p, in 10 equally divided doses at 3.5 days interval) in C57BL/6 J mice. TEL significantly downregulated glial fibrillary acidic protein (GFAP), inducible nitric oxide synthase (iNOS), TNFα and IL1β expressions and nitric oxide (NO) content. Significant upregulation glial cell derived neurotrophic factor (GDNF) expression and increased glutathione (GSH) content reveal the ameliorating effects of TEL on astroglial functions. On the other hand, TEL upregulated tyrosine hydroxylase (TH), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT2) expressions. Finally, TEL improved dopamine and its turnover and restored locomotor performance. Present experiment reveals that TEL has the potential to alleviate astroglial...Continue Reading

References

Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jul 1, 1994·Brain Pathology·L F Eng, R S Ghirnikar
Nov 1, 1993·Journal of Neurochemistry·J I SagaraS Bannai
Jul 31, 1998·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·L L PeñaM Castaño
Dec 13, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·T ArakiY Itoyama
Jan 5, 2002·Journal of Neuroscience Methods·Pierre O FernagutFrançois Tison
Jan 31, 2002·World Journal of Gastroenterology : WJG·Guo-Qing ZangDan Liao
Jun 22, 2002·Annals of the New York Academy of Sciences·Bin LiuJau-Shyong Hong
Apr 5, 2003·The International Journal of Biochemistry & Cell Biology·M J McKinleyS Y Chai
Mar 25, 2004·Neurochemical Research·Simon J R HealesJohn M Land
Feb 22, 2005·Molecular Aspects of Medicine·Andrew J Duncan, Simon J R Heales
Jun 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·He-Jin LeeSeung-Jae Lee
Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sen WangGang Hu
Sep 24, 2005·American Journal of Physiology. Cell Physiology·Patricia E GallagherE Ann Tallant
Nov 22, 2005·Neurobiology of Disease·Peter KlivenyiM Flint Beal
May 5, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Saurav BrahmachariKalipada Pahan
Oct 3, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Timothy Schallert
Oct 1, 2008·Progress in Neurobiology·Ana SaavedraEmília P Duarte
Jun 23, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Young C ChungByung K Jin
Nov 17, 2010·Frontiers in Neuroanatomy·Tomás González-HernándezJavier Castro-Hernandez
May 13, 2011·Acta Neuropathologica·Lisa FellnerNadia Stefanova
Jun 8, 2013·The Journal of Biological Chemistry·Saurabh KhasnavisKalipada Pahan
Aug 20, 2014·Frontiers in Cellular Neuroscience·Ricardo CabezasGeorge E Barreto

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Citations

Jun 12, 2019·BioFactors·Abid BhatMeena K Sakharkar
Sep 26, 2019·Neural Regeneration Research·Rubaiya TabassumJunyang Jung
Jul 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abid BhatMeena Kishore Sakharkar
Sep 17, 2021·Phytotherapy Research : PTR·Maryam MohseniMohammad Bagherniya

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
light microscopy

Software Mentioned

Graph pad Prism
SYSTAT
Motic

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