Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Minoru SatohNaoki Kashihara

Abstract

Hypertensive vascular disorders are characterized by endothelial dysfunction. Loss of renal autoregulation causes glomerular hypertension. However, the relationship between the autoregulatory response and glomerular damage has not been well examined. We examined the contributions of uncoupled endothelial nitric oxide synthase (eNOS) in hypertensive renal disease, and the relationship between the degree of autoregulation impairment and glomerular injury. We also investigated the effects of telmisartan on eNOS coupling and renal autoregulation. Male Dahl salt-sensitive hypertensive (DS) rats (14-week old) fed an 8% salt diet were used to examine endothelial dysfunction and impaired renal autoregulation caused by glomerular hypertension. Some DS rats were treated with telmisartan (3.0 mg kg(-1) day(-1)), an angiotensin receptor blocker, for 2 weeks. Increased superoxide production and decreased nitric oxide production, as detected by fluorescent indicator perfusion methods, were observed in the glomeruli and arterioles of hypertensive DS rats. Telmisartan improved the imbalance of superoxide and nitric oxide in the glomeruli and arterioles. Decreased serum tetrahydrobiopterin levels and coupled eNOS seen in the DS rat kidney were ...Continue Reading

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Citations

Oct 1, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sachiko MatsumotoToshiyuki Miyata
Sep 3, 2013·Nitric Oxide : Biology and Chemistry·Tushar V GadkariMahesh S Joshi
Jul 9, 2010·PPAR Research·Tamás Roszer, Mercedes Ricote
Jun 24, 2014·Clinical and Experimental Nephrology·Yoshihito TashiroKoichi Endo
Jan 9, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naruya Tomita, Norio Komai
Apr 3, 2015·Physiological Reviews·Mattias CarlströmWilliam J Arendshorst
Dec 15, 2010·Journal of Hypertension·Noboru Toda, Kikuo Arakawa
Dec 17, 2019·Hypertension·Jin WeiRuisheng Liu
Aug 22, 2012·Journal of Toxicologic Pathology·Masako ImaokaAtsushi Sanbuissho
Oct 10, 2018·Nephrology·Fang ZhongJohn C He
Aug 1, 2012·Physiological Research·J ZichaJ Kuneš

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