Abstract
Telmisartan, an angiotensin type 1 receptor blocker, is widely used for the treatment of hypertension and related cardiovascular and organ damage. We here describe the effects of telmisartan on food intake and body weight using C57BL/6N mice, KKAy mice that overexpress agouti protein (a mouse model of type 2 diabetes with obesity), and mice deficient for angiotensin II-1a receptor. Telmisartan combined with a high-fat diet significantly reduced food intake and body weight gain in the three groups of mice compared with respective control animals that were fed the high-fat diet without telmisartan. Telmisartan did not induce taste aversion or affect energy expenditure. Intracerebroventricular administration of agouti-related protein, a potent antagonist of the melanocortin 3 receptor (MC3-R) and melanocortin 4 receptor (MC4-R), did not stimulate feeding in telmisartan-treated mice. Telmisartan administration enhanced the alpha-melanocyte stimulating hormone-induced suppression of food intake. This study highlights a potential role for telmisartan in hypothalamic feeding regulation, including melanocortin receptors-mediated suppression of food intake and body weight gain.:
References
May 29, 1992·Biochemical and Biophysical Research Communications·H SasamuraV J Dzau
Aug 11, 1995·The Journal of Biological Chemistry·T SugayaA Otsuka
May 1, 1995·Hypertension·M de GasparoP B Timmermans
Oct 27, 1994·Nature·D LuW O Wilkison
Jul 19, 2001·The Journal of Biological Chemistry·E D Rosen, B M Spiegelman
Jun 19, 2002·Naunyn-Schmiedeberg's Archives of Pharmacology·P GohlkeJ Culman
Mar 1, 2003·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G H GoossensM A van Baak
Mar 10, 2004·Hypertension·Stephen C BensonTheodore W Kurtz
Mar 30, 2004·Diabetes Care·Harrihar A Pershadsingh, Theodore W Kurtz
Apr 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·James R Sowers
Jan 29, 2005·Diabetes Care·Sachiko HonjoHiroyuki Koshiyama
Mar 29, 2005·Diabetes·Laurent Yvan-CharvetAnnie Quignard-Boulange
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet
Mar 29, 2006·Hypertension·Ken SugimotoTheodore W Kurtz
May 24, 2006·Hypertension·Kana ArakiHironobu Yoshimatsu
Nov 2, 2006·Endocrine Reviews·Roger D Cone
Apr 6, 2007·European Journal of Pharmacology·Jörg-Peter VoigtHeidrun Fink
Aug 2, 2007·American Journal of Therapeutics·Zafar H IsrailiManuel Velasco
Oct 2, 2009·Metabolism: Clinical and Experimental·Gregory AubertAnne Zanchi
Feb 3, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Helge Müller-FielitzWalter Raasch
Citations
Sep 27, 2014·British Journal of Pharmacology·Helge Müller-FielitzWalter Raasch
Feb 20, 2016·British Journal of Pharmacology·Martina WinklerWalter Raasch
Jan 31, 2020·Metabolic Brain Disease·Daniela PechlivanovaAlexander Stoynev