Telmisartan/Hydrochlorothiazide: a review of its use as fixed-dose combinations in essential hypertension.

Drugs
Greg L Plosker, William B White

Abstract

Fixed-dose combinations of telmisartan and hydrochlorothiazide (HCTZ) [Micardis Plus, Micardis HCT, PritorPlus] are available in many countries for the treatment of patients with essential hypertension. Combining the angiotensin II receptor antagonist (angiotensin II receptor blocker [ARB]) telmisartan with the thiazide diuretic HCTZ provides antihypertensive therapy with complementary mechanisms of action. In the US and EU, telmisartan/HCTZ is approved for patients whose hypertension is not adequately controlled with telmisartan monotherapy; US labelling for the fixed-dose combination also includes inadequate control of blood pressure (BP) with HCTZ monotherapy.The antihypertensive efficacy of once-daily telmisartan/HCTZ has been demonstrated in several large, randomized trials in patients with stages 1 and 2 hypertension. The addition of HCTZ to telmisartan achieved significant reductions in BP in nonresponders to telmisartan monotherapy, and the antihypertensive efficacy of telmisartan/HCTZ was similar to or significantly greater than that of various comparator agents. Moreover, in studies that used ambulatory BP monitoring, telmisartan/HCTZ provided consistent 24-hour BP reductions throughout morning, daytime and night-time...Continue Reading

References

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Citations

Aug 17, 2010·Expert Opinion on Pharmacotherapy·Lars Christian Rump, Lorenz Sellin
May 20, 2014·Current Medical Research and Opinion·Steen NeldamJoel M Neutel
Nov 26, 2010·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Marit D Moen
Oct 12, 2012·Expert Opinion on Pharmacotherapy·L M Ruilope, Helmut Schumacher

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