Telocytes in human epicardium.

Journal of Cellular and Molecular Medicine
Laurentiu M PopescuSawa Kostin

Abstract

The existence of the epicardial telocytes was previously documented by immunohistochemistry (IHC) or immunofluorescence. We have also demonstrated recently that telocytes are present in mice epicardium, within the cardiac stem-cell niches, and, possibly, they are acting as nurse cells for the cardiomyocyte progenitors. The rationale of this study was to show that telocytes do exist in human (sub)epicardium, too. Human autopsy hearts from 10 adults and 15 foetuses were used for conventional IHC for c-kit/CD117, CD34, vimentin, S-100, τ, Neurokinin 1, as well as using laser confocal microscopy. Tissue samples obtained by surgical biopsies from 10 adults were studied by digital transmission electron microscopy (TEM). Double immunolabelling for c-kit/CD34 and, for c-kit/vimentin suggests that in human beings, epicardial telocytes share similar immunophenotype features with myocardial telocytes. The presence of the telocytes in human epicardium is shown by TEM. Epicardial telocytes, like any of the telocytes are defined by telopodes, their cell prolongations, which are very long (several tens of μm), very thin (0.1-0.2 μm, below the resolving power of light microscopy) and with moniliform configuration. The interconnected epicardial...Continue Reading

References

Dec 22, 1999·Microscopy Research and Technique·M S Faussone-Pellegrini, L Thuneberg
Sep 25, 2003·Cell·Antonio P BeltramiPiero Anversa
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Jun 15, 2004·Journal of the American College of Cardiology·José MileiGiuseppe Ambrosio
Jun 21, 2005·Journal of Cellular and Molecular Medicine·Sanda M CionteaL M Popescu
Jun 21, 2005·Journal of Cellular and Molecular Medicine·L M PopescuCarmen Ardeleanu
Jul 26, 2005·Journal of Molecular and Cellular Cardiology·Patrick MüllerMichael Böhm
Dec 21, 2005·Journal of Cellular and Molecular Medicine·M E Hinescu, L M Popescu
Feb 8, 2006·Annual Review of Physiology·Michael Rubart, Loren J Field
Feb 28, 2006·Nature Clinical Practice. Cardiovascular Medicine·Daniele TorellaBernardo Nadal-Ginard
Mar 28, 2006·Journal of Cellular and Molecular Medicine·M E HinescuL M Popescu
Jun 27, 2006·Journal of Cellular and Molecular Medicine·L M PopescuE Mandache
Mar 16, 2007·Annals of the New York Academy of Sciences·Laurentiu M PopescuDragos Cretoiu
Mar 24, 2007·Cellular and Molecular Life Sciences : CMLS·E M Winter, A C Gittenberger-de Groot
Jun 2, 2007·Journal of Molecular Histology·Mihail E HinescuLaurentziu M Popescu
Jul 20, 2007·Journal of Cellular and Molecular Medicine·Feixiong Zhang, Kishore B S Pasumarthi
Oct 20, 2007·Circulation Research·Federica LimanaMaurizio C Capogrossi
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Lucia FormigliDaniele Bani
Nov 28, 2007·TheScientificWorldJournal·Heleen Lie-VenemaAdriana C Gittenberger-de Groot
Jan 16, 2008·Journal of Cellular and Molecular Medicine·M E HinescuM-S Faussone-Pellegrini
Apr 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Paul R Riley
Jun 21, 2008·Journal of Molecular and Cellular Cardiology·Maria Grazia PerinoKenneth R Boheler
Jul 5, 2008·Journal of Molecular and Cellular Cardiology·Jan KajsturaAnnarosa Leri
Jul 29, 2008·Current Opinion in Organ Transplantation·Carlos Clavel, Catherine M Verfaillie
Jul 31, 2008·Stem Cell Reviews·Peter J Quesenberry, Jason M Aliotta
Aug 2, 2008·Journal of Cellular and Molecular Medicine·Mihaela GherghiceanuL M Popescu
Aug 8, 2008·Journal of Cellular and Molecular Medicine·Catharina NesselmannGustav Steinhoff
Aug 30, 2008·Regenerative Medicine·Bin Zhou, William T Pu
Sep 9, 2008·Journal of Molecular and Cellular Cardiology·Manhal HabibLior Gepstein
Nov 26, 2008·Circulation Research·Massimiliano GnecchiVictor J Dzau
Dec 9, 2008·Current Opinion in Organ Transplantation·Joshua M Hare, Sandra V Chaparro
Jan 1, 2007·Drug Discovery Today. Disease Mechanisms·Annarosa LeriPiero Anversa
Jan 24, 2009·Journal of Molecular and Cellular Cardiology·Tania ZagliaSimonetta Ausoni
Feb 3, 2009·Journal of Cellular and Molecular Medicine·S Kostin, L M Popescu
Feb 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yvonne N TalliniMichael I Kotlikoff
Mar 7, 2009·PloS One·Alex YuanDebora B Farber
Mar 12, 2009·Pediatric Cardiology·Henry M SucovMohammad Pashmforoush
Apr 23, 2009·Journal of Cellular and Molecular Medicine·L M PopescuMaria Simonetta Faussone-Pellegrini
Apr 23, 2009·Journal of Cellular and Molecular Medicine·L SuciuC G Manole

❮ Previous
Next ❯

Citations

Dec 22, 2010·Cell and Tissue Research·Mihail E HinescuLaurentiu M Popescu
Feb 22, 2012·Cell and Tissue Research·Mihaela Gherghiceanu, Laurentiu M Popescu
Feb 10, 2012·Pancreas·Mihnea I Nicolescu, Laurentiu M Popescu
Jun 2, 2012·Cells, Tissues, Organs·Goran Radenkovic, Mirjana Abramovic
Sep 12, 2012·Journal of Translational Medicine·Yonghua ZhengXiangdong Wang
Feb 14, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Sanda M CretoiuLaurentiu M Popescu
Jan 15, 2014·Cell and Tissue Research·Mirjana AbramovicAleksandra Velickov
Dec 17, 2015·Experimental and Therapeutic Medicine·Ping YangQiusheng Chen
Jan 31, 2016·Seminars in Cell & Developmental Biology·Yihua BeiJunjie Xiao
Feb 26, 2016·Seminars in Cell & Developmental Biology·Sawa Kostin
Jan 31, 2016·Seminars in Cell & Developmental Biology·Maria-Simonetta Faussone-Pellegrini, Mihaela Gherghiceanu
Oct 17, 2015·Journal of Cellular and Molecular Medicine·Chi ChiXiao-Jun Yang
Mar 1, 2013·Journal of Cellular and Molecular Medicine·Mirko ManettiLidia Ibba-Manneschi
Dec 16, 2010·Journal of Cellular and Molecular Medicine·Jin ZhouChangyong Wang
Aug 31, 2012·Cell Biology International·Mugurel Constantin RusuDumitru Păduraru
Nov 6, 2013·Journal of Cellular and Molecular Medicine·Xiaoke ChenQun Wang
Mar 26, 2011·Journal of Cellular and Molecular Medicine·I CantareroC Junquera
Sep 8, 2011·Journal of Cellular and Molecular Medicine·C G ManoleL M Popescu
May 26, 2011·Journal of Cellular and Molecular Medicine·L M PopescuB O Popescu
Aug 4, 2011·Journal of Cellular and Molecular Medicine·Y ZhengX Wang
Dec 17, 2011·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Mihnea I NicolescuLaurentiu M Popescu
Oct 8, 2011·Journal of Cellular and Molecular Medicine·Carmen Ardeleanu, Gianni Bussolati
Aug 19, 2010·Journal of Cellular and Molecular Medicine·Mihaela GherghiceanuL M Popescu
Nov 3, 2010·Journal of Cellular and Molecular Medicine·E MandacheL M Popescu
Apr 30, 2013·Journal of Cellular and Molecular Medicine·Lucio Díaz-FloresJuan F Madrid
Dec 1, 2010·Journal of Cellular and Molecular Medicine·L SuciuL M Popescu
Dec 5, 2012·Journal of Cellular and Molecular Medicine·Baoyin ZhaoDongqing Cai
Mar 23, 2012·Journal of Cellular and Molecular Medicine·Raymund E HorchAndreas Arkudas
Jul 26, 2011·Journal of Cellular and Molecular Medicine·Florina M BojinVirgil Paunescu
Feb 8, 2013·Journal of Cellular and Molecular Medicine·Lara S CorradiSebastião R Taboga
Mar 31, 2011·Journal of Cellular and Molecular Medicine·V B CismasiuL M Popescu
Dec 23, 2011·Journal of Cellular and Molecular Medicine·Laura C SuciuLaurentiu M Popescu
Dec 18, 2012·Journal of Cellular and Molecular Medicine·Guisheng QiTongyu Zhu
Mar 24, 2011·Journal of Cellular and Molecular Medicine·Mihaela Gherghiceanu, Laurentiu M Popescu
May 23, 2012·Journal of Cellular and Molecular Medicine·Zhuzhi WenJingfeng Wang
Nov 9, 2010·Journal of Cellular and Molecular Medicine·I Cantarero CarmonaC Junquera Escribano
Apr 17, 2012·Journal of Cellular and Molecular Medicine·Laura CeafalanOlga Simionescu
Aug 7, 2012·Journal of Cellular and Molecular Medicine·Maksym I HarhunMarcus Reddy
Oct 25, 2013·Journal of Cellular and Molecular Medicine·Maria-Giuliana VannucchiMaria-Simonetta Faussone-Pellegrini
Jul 1, 2014·Journal of Cellular and Molecular Medicine·Qingfeng MiaoPhilip Wong
Nov 26, 2013·Journal of Cellular and Molecular Medicine·Junjie XiaoChangqing Yang
Mar 29, 2014·Journal of Cellular and Molecular Medicine·Yonghua ZhengXiangdong Wang
Jan 29, 2014·Journal of Cellular and Molecular Medicine·Jingwei ShengPhilip Wong
Feb 19, 2014·Journal of Cellular and Molecular Medicine·Daniele Bani, Silvia Nistri
Aug 19, 2014·Journal of Cellular and Molecular Medicine·Fei WangChangqing Yang
Apr 25, 2014·Journal of Cellular and Molecular Medicine·Liping LiTongyu Zhu

❮ Previous
Next ❯

Methods Mentioned

BETA
transmission electron microscopy
coronary artery bypass
confocal microscopy
biopsy

Software Mentioned

- SIS
Adobe Photoshop
iTEM
AxioVision

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Journal of Cellular and Molecular Medicine
Mihaela GherghiceanuLaurentiu M Popescu
Cells, Tissues, Organs
Laura C SuciuMaria-Simonetta Faussone-Pellegrini
Journal of Cellular and Molecular Medicine
Mihaela Gherghiceanu, Laurentiu M Popescu
Journal of Cellular and Molecular Medicine
Sawa Kostin
© 2021 Meta ULC. All rights reserved