Telocytes in minor salivary glands of primary Sjögren's syndrome: association with the extent of inflammation and ectopic lymphoid neogenesis

Journal of Cellular and Molecular Medicine
Alessia AlunnoMirko Manetti

Abstract

It has been recently reported that telocytes, a stromal (interstitial) cell subset involved in the control of local tissue homeostasis, are hampered in the target organs of inflammatory/autoimmune disorders. Since no data concerning telocytes in minor salivary glands (MSGs) are currently available, aim of the study was to evaluate telocyte distribution in MSGs with normal architecture, non-specific chronic sialadenitis (NSCS) and primary Sjögren's syndrome (pSS)-focal lymphocytic sialadenitis. Twelve patients with pSS and 16 sicca non-pSS subjects were enrolled in the study. MSGs were evaluated by haematoxylin and eosin staining and immunofluorescence for CD3/CD20 and CD21 to assess focus score, Tarpley biopsy score, T/B cell segregation and germinal center (GC)-like structures. Telocytes were identified by immunoperoxidase-based immunohistochemistry for CD34 and CD34/platelet-derived growth factor receptor α double immunofluorescence. Telocytes were numerous in the stromal compartment of normal MSGs, where their long cytoplasmic processes surrounded vessels and encircled both the excretory ducts and the secretory units. In NSCS, despite the presence of a certain degree of inflammation, telocytes were normally represented. Conv...Continue Reading

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Citations

Mar 30, 2016·Seminars in Cell & Developmental Biology·Dragos Cretoiu, Sanda Maria Cretoiu
Aug 30, 2016·Seminars in Cell & Developmental Biology·Dragos CretoiuSanda Maria Cretoiu
Mar 10, 2017·Autoimmunity·Ana Raquel Rodrigues, Raquel Soares
Jul 18, 2017·Journal of Cellular and Molecular Medicine·Mirca MariniMirko Manetti
Aug 28, 2018·Journal of Cellular Physiology·Meng-Juan LinBao-Ping Yu
Feb 28, 2018·Scientific Reports·Irene RosaMirko Manetti
Jun 25, 2019·Journal of Cellular and Molecular Medicine·Shinan LiShaoheng He
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Aug 28, 2015·Journal of Cellular and Molecular Medicine·Joanna DawidowiczKrzysztof Maksymowicz
Oct 17, 2015·Journal of Cellular and Molecular Medicine·Chi ChiXiao-Jun Yang
Feb 2, 2016·Journal of Cellular and Molecular Medicine·Alessia AlunnoMirko Manetti
Jan 26, 2016·Journal of Cellular and Molecular Medicine·Hui ZhangXiaoquan Guo
Jan 11, 2020·Frontiers in Immunology·Shanshan LuoDesheng Hu
Aug 23, 2020·International Journal of Molecular Sciences·Eloisa RomanoMirko Manetti
Jul 16, 2015·Journal of Cellular and Molecular Medicine·Radu AlbulescuLaurentiu M Popescu
Jan 20, 2016·Journal of Cellular and Molecular Medicine·Ting XuHongqi Zhang
Dec 23, 2020·Journal of Cellular and Molecular Medicine·Irene RosaMirko Manetti

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Methods Mentioned

BETA
light microscopy
biopsies
biopsy

Software Mentioned

Leica LAS

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