PMID: 11328407May 1, 2001Paper

Telomerase-A molecular marker for cervical cancer screening

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Vijay G ReddyN Singh

Abstract

Cervical cancer is one of the most common cancers in women and can be routinely screened for by the Papanicolaou smear. Screening for HPV high-risk types 16 and 18 has augmented the sensitivity of this test, but still some cases remain undetected. We have investigated the utility of assaying telomerase activity as a possible screening marker for cervical cancer. Telomerase activity was studied in relation to HPV 16/18 infection, Papanicolaou smear cytopathology, and biopsy histopathology in a total of 88 subjects, consisting of 29 cervical cancer cases, 19 control hysterectomy samples, 16 precancerous cervical scrapes, 6 cervical samples from other gynecological malignancies, and 18 normal healthy cervical scrapings. Telomerase activity was detected in 96.5% of cervical tumor samples and in 68.7% of premalignant cervical scrapings but was not detected in control hysterectomy samples and in cervical scrapings of normal healthy controls. Telomerase assay had a diagnostic accuracy of 95.8 in tissue samples, 79.1 in scrapings and 91.2 in all. Whereas HPV-16/18 subtyping had a diagnostic accuracy of 89.5% in tissue samples, 70.5% in scrapings, and 82.1% in all. There was also 71% agreement between telomerase activity and HPV-16/18 i...Continue Reading

Citations

Jan 4, 2005·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·A SinghN Singh
Sep 18, 2010·Journal of Experimental & Clinical Cancer Research : CR·Peng Guo-QingTian Yan
Nov 1, 2007·Expert Opinion on Medical Diagnostics·Jeong-Hoon Bae, Jong-Sup Park
May 31, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chi-Hau Chen, Ruey-Jien Chen
May 11, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A Sharma, U Menon
Feb 19, 2002·Oncogene·Eiso Hiyama, Keiko Hiyama
Jan 30, 2004·Cancer Control : Journal of the Moffitt Cancer Center·Dale VimalachandranJohn P Neoptolemos
May 20, 2018·Molecular Diagnosis & Therapy·Anna PańczyszynGrzegorz Głąb

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