Telomerase activity and telomere length in human tumor cells with acquired resistance to anticancer agents

Journal of Chemotherapy
V SmithA M Burger

Abstract

Telomeres and telomerase are targets for anticancer drug development and specific inhibitors are currently under clinical investigation. However, it has been reported that standard cytotoxic agents can affect telomere length and telomerase activity suggesting that they also have of a role in drug resistance. in this study, telomere lengths and telomerase activity as well as drug efflux pump expression, glutathione (GSH) levels and polyadenosine-ribose polymerase (PARP) cleavage were assessed in a panel of human tumor cell lines made resistant to vindesine, gemcitabine and cisplatin. these included two lung cancer cell lines resistant to vindesine (LXFL 529L/Vind, LXFA 526L/Vind), a renal cancer cell line (RXF944L/Gem) and an ovarian cancer cell line (AG6000) resistant to gemcitabine, and one resistant to cisplatin (ADDP). The resistant clones were compared to their parental lines and evaluated for cross resistance to other cytotoxic agents. Several drug specific resistance patterns were found, and various complex patterns of cross resistance emerged from some cell lines, but these mechanisms of resistance could not be related to drug efflux pump expression, GSH levels or pARp cleavage. However, all displayed changes in telomera...Continue Reading

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Citations

May 15, 2015·Journal of the National Cancer Institute·Kishore B ChallagundlaMuller Fabbri
Nov 13, 2014·Cellular and Molecular Life Sciences : CMLS·Florian T UngerKerstin A David
Jul 28, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marta GladychBlazej Rubis
Jun 18, 2017·Cellular and Molecular Life Sciences : CMLS·Natalia LipinskaBlazej Rubis
Sep 20, 2019·International Journal of Molecular Sciences·Angela GalardiAngela Di Giannatale
Sep 16, 2017·Frontiers in Molecular Neuroscience·Federica CiregiaGiuseppe Palmisano

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