Telomerase activity in breast cancer patients: association with poor prognosis and more aggressive phenotype

Medical Oncology
Ana KulićMaja Sirotković-Skerlev

Abstract

Telomerase expression is an important mechanism of tumor unlimited replicative potential. The aim of this study was to evaluate prognostic impact of telomerase activity in breast cancer patients and to correlate telomerase activity with established prognostic factors. We analyzed tissue of 102 malignant breast lesions and 20 healthy breast tissues. Telomerase activity was determined by telomeric repeat amplification protocol assay. Telomerase activity was present in 77 (75.49 %) of 102 breast cancers. Telomerase activity in breast cancers was statistically significantly higher in comparison with the activity in normal breast tissue. The levels of telomerase activity were significantly positively correlated with tumor size, axillary nodal status, histological grade, HER-2/neu protein expression in tumor tissue and expression of the nuclear antigen Ki-67. A statistically significant negative correlation was found between the presence of ER and telomerase activity. There was no correlation between telomerase activity and concentration of PR or the age of patients. Kaplan-Meier analysis showed that patients with higher telomerase activity had significantly shorter 10-year disease-free survival (p < 0.0001) and 10-year overall survi...Continue Reading

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Citations

Aug 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Teisha J RowlandThomas R Cech
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hugo A Ceja-RangelLuis Benítez-Bribiesca
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Mar 19, 2020·Cancer Management and Research·Mariana MoraisRui Medeiros
Sep 10, 2020·Methods and Protocols·Alice BradfieldDharani K Hapangama
Oct 28, 2019·ACS Omega·Diana C Díaz-CartagenaCarlos R Cabrera

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