Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid

Surgery
M SajiM A Zeiger

Abstract

Although fine-needle aspiration (FNA) is 90% sensitive in the detection of papillary carcinoma (PC) of the thyroid, its specificity has been reported as low as 52%. Consequently, patients who have an FNA suspicious for PC may undergo operation for a benign process. The ribonucleoprotein telomerase has been noted to be activated in a wide variety of carcinomas. We examined 30 PCs for telomerase activity to determine whether this would be a useful adjunct to FNA in the diagnosis of lesions suspicious for PC. Standard telomere repeat amplification protocol assays were performed on fresh frozen tissue samples from 30 PCs, 3 benign nodules, and 10 normal thyroids. Telomerase activity was documented in 20 of 30 (67%) of the PCs, 0 of 3 benign nodules, and 0 of 10 normal thyroids. In all, 11 of the 20 PCs had FNA cytology that was nondiagnostic of PC, and 2 of the benign nodules had FNA that was suspicious for PC. The telomerase assay appears useful in the distinction of benign from malignant thyroid lesions that have FNA suspicious for but not diagnostic of PC. On the basis of these findings, a prospective trial examining telomerase activity in FNAs suspicious for thyroid cancer has been initiated.

References

Sep 1, 1982·The American Journal of Medicine·B HambergerA R Zinsmeister
Sep 1, 1982·Texas Medicine·S RubenfeldH J Spjut
Apr 1, 1995·Current Opinion in Genetics & Development·C B Harley, B Villeponteau
Apr 1, 1994·Current Opinion in Genetics & Development·C W Greider
Jan 1, 1994·Annual Review of Medicine·J A Fagin
Jun 3, 1994·Cell·E H Blackburn
Feb 15, 1993·Annals of Internal Medicine·H Gharib, J R Goellner
Nov 1, 1995·Molecular Medicine Today·J W Shay

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Citations

Aug 30, 2000·Journal of Surgical Oncology·M GogginsR Hruban
Jun 16, 2001·The Journal of Pathology·P MatthewsD Wynford-Thomas
Dec 18, 2001·Seminars in Surgical Oncology·T Weber, E Klar
Nov 13, 2008·Cytotechnology·Eiso Hiyama, Keiko Hiyama
Jan 23, 2004·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L Karayan-TaponJ L Kraimps
Jun 3, 2000·The Surgical Clinics of North America·R L RossiR M Rossi
May 22, 2003·Cancer Letters·Eiso Hiyama, Keiko Hiyama
Oct 12, 2001·The Journal of Steroid Biochemistry and Molecular Biology·C Orlando, S Gelmini
Aug 30, 2003·Surgical Oncology·Dorry L SegevMartha A Zeiger
Feb 19, 1999·Journal of the American College of Surgeons·E L Kaplan
Apr 10, 2002·Clinical Endocrinology·Bryan R HaugenMichael T McDermott
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C W Greider
Jan 26, 2000·Thyroid : Official Journal of the American Thyroid Association·C Y LoJ M Luk
Sep 26, 2008·Thyroid : Official Journal of the American Thyroid Association·Yongchun WangMartha A Zeiger
Jan 15, 2000·Journal of Clinical Gastroenterology·Y OkusaN Shinomiya
Apr 8, 1999·Thorax·K DhaeneE Van Marck
May 28, 2002·Journal of Endocrinological Investigation·A M StraightG L Francis
Jun 1, 2001·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M T SiddiquiM Saji
Oct 20, 2009·The Surgical Clinics of North America·Meredith A Kato, Thomas J Fahey
Oct 28, 2005·Advances in Surgery·Carrie C Lubitz, Thomas J Fahey
Jun 26, 2001·The Journal of Surgical Research·S J ChouY C Liu
Jul 19, 2011·The American Journal of Pathology·Yongchun WangChristopher B Umbricht
Apr 6, 2001·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·Y C Oertel, J E Oertel
Jan 22, 2008·American Journal of Surgery·Sandeepa MusunuruHerbert Chen
Feb 19, 2002·Oncogene·Jeremy D HensonRoger R Reddel
Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Lisong TengThomas J Fahey
Oct 3, 2008·Journal of Enzyme Inhibition and Medicinal Chemistry·Akio NagasakaKatsumi Iwase
Oct 11, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A OhaliR Zaizov
Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·X De DekenF Miot

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