Telomerase activity is elevated in early S phase in hamster cells

Biochemical and Biophysical Research Communications
P A KrukV A Bohr

Abstract

Telomerase is a ribonucleoprotein that elongates telomeric repeats de novo. We examined the possibility that telomerase activity is cell cycle regulated by examining telomerase activity in cell cycle synchronized Chinese hamster ovary (CHO) B11 cells. Overall telomerase activity was similar in growing and quiescent cells. Further, cells synchronized in G1, S, or G2/M showed similar levels of telomerase activity. However, a detailed analysis of cells within S phase showed that there was a higher level of telomerase activity in early S phase when compared with other points in the cell cycle. These results suggest a relationship between telomerase activity and cell cycle regulation.

References

Apr 18, 1991·Nature·E H Blackburn
Sep 1, 1996·Molecular Biology of the Cell·K J Buchkovich, C W Greider

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Citations

Jan 7, 2011·Journal of Experimental & Clinical Cancer Research : CR·Yingying LuMengbiao Yuan
Feb 21, 2002·Cancer Investigation·Jianming WenLaibao Sun
Apr 7, 2000·The American Journal of Pathology·P RudolphR Parwaresch
Dec 18, 1998·The Journal of Investigative Dermatology·J R BickenbachP Boukamp
Jul 20, 1999·The Journal of Biological Chemistry·K TamuraH Takahashi

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