Telomerase activity is induced by the stimulation to antigen receptor in human peripheral lymphocytes

Biochemical and Biophysical Research Communications
H Igarashi, N Sakaguchi

Abstract

Impairment of replicating DNA ends by normal DNA polymerases and the gradual shrink of the ends of linear chromosomes (telomeres) is recently considered to play a role for the limited growth of cells. Telomerase activity, that uses an RNA template to extend telomeric DNA, appears in the malignant transformation of human cells. Freshly isolated normal lymphoid cells do not express any detectable telomerase activity. Interestingly, anti-CD3 monoclonal antibody (mAb) induces telomerase activity in human peripheral T cells. Ca ionophore and phorbol 12,13-dibutyrate (PDB), which are considered as the stimulants that bypass T cell receptor (TCR) signaling, also induce telomerase activity. These results clearly demonstrate that telomerase activity appears in normal lymphoid cells and suggest that antigen receptor-mediated induction of telomerase activity is playing a role in the proliferation of human T cells in the immune response.

Citations

Dec 12, 2001·HIV Medicine·V TuckerM J Browning
Sep 1, 1996·Molecular Biology of the Cell·K J Buchkovich, C W Greider
Mar 3, 2007·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Daitaro Kurosaka
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C W Greider
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·K LiuN P Weng
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·N P WengR J Hodes
Apr 29, 1998·Cancer Investigation·P T Rowley
Nov 14, 1998·Annals of Medicine·V UrquidiS Goodison
Mar 16, 2016·Journal of Immunology Research·Jue LinElizabeth H Blackburn
May 3, 2006·The Journal of Experimental Medicine·Sascha TrappNikolaus Osterrieder
Apr 2, 1998·Experimental Cell Research·T M BryanR R Reddel
Apr 28, 1997·Virology·J P PommierF D Boussin
Apr 20, 2000·Journal of Veterinary Internal Medicine·E A SpanglerD E Shippen
Mar 10, 1998·Genes, Chromosomes & Cancer·B A Kosciolek, P T Rowley
Aug 15, 2003·World Journal of Gastroenterology : WJG·Dao-Yong LiuChong-Zhi Zhou
Feb 19, 2002·Oncogene·Junko H OhyashikiKazuma Ohyashiki
Jul 20, 2006·Journal of Biomedical Science·Yi-Jui ChenTzu-Chien V Wang
Apr 3, 2019·International Journal of Rheumatic Diseases·Kazuhiro Otani, Daitaro Kurosaka
Jul 20, 1999·The Journal of Biological Chemistry·K TamuraH Takahashi
Jul 30, 2020·Journal of Leukocyte Biology·Aimee M MerinoFrank Cichocki
May 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C Chaves-DiasM A Beaven
Jan 1, 1997·Hematology·X R JiangA C Newland
Feb 15, 2019·Frontiers in Immunology·Graham Pawelec
Jan 22, 1998·Biochemical and Biophysical Research Communications·W C KuT C Wang
Jun 26, 1998·Current Opinion in Cell Biology·F B JohnsonL Guarente

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.