Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors.

Blood
Mathias LichterfeldXu G Yu

Abstract

Exhaustion of virus-specific T cells may play an important role in the pathophysiology of chronic viral infections. Here, we analyzed telomere length and telomerase activity in HIV-1-specific CD8+ T cells from progressors or controllers to determine underlying molecular pathways of T-cell exhaustion and senescence. Telomere lengths of HIV-1-specific CD8+ T cells from progressors were significantly shorter compared with autologous cytomegalovirus (CMV)/Epstein-Barr virus (EBV)-specific CD8+ T cells or bulk CD8+ T cells, while telomere lengths from controllers significantly exceeded those of autologous bulk CD8+ T cells and reached a similar level as HIV-1-specific CD8+ T cells collected during primary HIV-1 infection. Telomere length stabilization in controllers corresponded to high levels of constitutive telomerase activity, which was associated with preservation of cytotoxic and proliferative properties. Conversely, limited constitutive telomerase activity was observed in HIV-1-specific CD8+ T cells from progressors, although an increase in both telomere length and telomerase activity was achieved in antigenic-peptide-stimulated cells from progressors after blocking the PD-1/PD ligand 1 (PD-L1) pathway. Collectively, these dat...Continue Reading

References

Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·N P WengR J Hodes
Jun 1, 1996·The Journal of Experimental Medicine·N P WengR J Hodes
Oct 10, 1996·Experimental Cell Research·A G BodnarC P Chiu
May 20, 1998·Trends in Microbiology·K C Wolthers, F Miedema
Mar 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A MiguelesM Connors
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Sep 1, 2001·Trends in Molecular Medicine·S J O'BrienM Carrington
Oct 12, 2001·Immunology Letters·S A Migueles, M Connors
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Sep 5, 2002·Nature Reviews. Immunology·Richard J HodesNan-ping Weng
Dec 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Karen S HathcockRichard J Hodes
Apr 12, 2003·Blood·Alexander RothRosalie M Luiten
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beth D JamiesonSteven Wolinsky
Mar 27, 2004·Current HIV Research·Rita B Effros
Sep 3, 2004·Nature Reviews. Immunology·Arne N AkbarMike Salmon
Nov 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirabelle DagaragRita B Effros
Mar 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu LiNan-ping Weng
Sep 17, 2005·Genes & Development·Titia de Lange
May 9, 2006·Experimental Gerontology·Christine FehrerGünter Lepperdinger
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Apr 11, 2007·The Journal of Experimental Medicine·Haina ShinE John Wherry
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fiona J PlunkettArne N Akbar
Dec 29, 2007·The Journal of Pathology·V Appay, D Sauce
Jul 17, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rita B EffrosKevin P High

❮ Previous
Next ❯

Citations

Aug 25, 2010·Immunologic Research·Tammy M Rickabaugh, Beth D Jamieson
Jul 9, 2011·Nature Immunology·E John Wherry
Mar 26, 2011·Nature Reviews. Immunology·Arne N Akbar, Sian M Henson
Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Fang WeiJames L Riley
Sep 9, 2010·Rejuvenation Research·Calvin B HarleyJoseph M Raffaele
Jul 1, 2010·AIDS·Katie WilliamsMathias Lichterfeld
Oct 17, 2013·PLoS Pathogens·Hiroyu HatanoSteven G Deeks
Oct 16, 2012·Current Pharmaceutical Design·Jennifer P Chou, Rita B Effros
Feb 27, 2013·Annals of Internal Medicine·Gregory D KirkDavid L Thomas
Oct 29, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Katharina Grabmeier-PfistershammerNorbert Kohrgruber
Apr 4, 2015·Viruses·Wasim AbbasGeorges Herbein
Apr 2, 2014·Mayo Clinic Proceedings·Philipp J HohensinnerCornelia M Weyand
Apr 4, 2013·Seminars in Immunology·Deanna A KulpaRafick-Pierre Sékaly
Apr 7, 2010·Ageing Research Reviews·Jun-Ping LiuHe Li
Oct 20, 2009·Trends in Pharmacological Sciences·Karen A O'ConnellJoel N Blankson
Jun 25, 2009·Gastroenterology·Arthur Y Kim, Raymond T Chung
Jan 16, 2010·European Journal of Immunology·Helge FrebelAnnette Oxenius
Mar 11, 2015·Retrovirology·Vijayakumar VeluEsaki M Shankar
Sep 4, 2012·Current Opinion in Virology·Zabrina L BrummeMark A Brockman
Sep 7, 2016·Genes·Vasileios KordinasStylianos Chatzipanagiotou
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asier Sáez-CiriónUNKNOWN ANRS EP36 HIV Controllers Study Group
Mar 14, 2019·Frontiers in Immunology·Joanna A WarrenNilu Goonetilleke
Mar 2, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louise A SwainsonJoseph M McCune
Jul 28, 2020·Cells·Daniel HumphreysTeresa Frisan
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven Russell FauceRita B Effros
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel E Kaufmann, Bruce D Walker

❮ Previous
Next ❯

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