Telomerase activity, TERT expression, hTERT promoter alterations, and alternative lengthening of the telomeres (ALT) in meningiomas - a systematic review

Neurosurgical Review
Louise StögbauerBenjamin Brokinkel

Abstract

Telomerase activity and (human) Telomerase Reverse Transcriptase (hTERT) expression are considered hallmarks in oncogenesis of neoplasms and are upregulated by alterations of the hTERT promoter. In meningiomas, numerous studies investigated hTERT expression, telomerase activity, promoter mutations, and methylations. Moreover, reports about hTERT-targeted chemotherapy in meningiomas have recently been published. We provide a systematic review of the literature about the role of hTERT in meningiomas. TERT expression and telomerase activity is found in benign and high-grade meningiomas and increase with WHO grade. Remarkably, rates of TERT expression/telomerase activity usually exceed mutation frequency and both telomerase activity and TERT expression have also been found in hTERT promoter wildtype meningiomas, indicating further mechanisms of TERT upregulation. Although hTERT promoter methylation has been reported in the vast majority of meningiomas, correlation with TERT expression remains controversial. Rates of promoter mutations, and methylation were shown to increase with rising WHO grade. Moreover, promoter methylation and mutations strongly correlate with prognosis. Although mutations predicted malignant progression, de no...Continue Reading

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Citations

Apr 25, 2019·International Journal of Molecular Sciences·Eishiro Mizukoshi, Shuichi Kaneko
Jul 10, 2020·Neuro-oncology Advances·Yasuhiro KuroiHidetoshi Kasuya
Aug 8, 2020·Journal of Radiation Research·Guangsheng ZhaiChuanzhao Li
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Akash J PatelTiemo J Klisch
Sep 6, 2020·Current Opinion in Oncology·Cristina BirzuFelix Sahm
Mar 16, 2021·Journal of Neuroradiology. Journal De Neuroradiologie·Ilah ShinSeung-Koo Lee
Jul 23, 2021·The Kaohsiung Journal of Medical Sciences·Fu-Ji LaiNing He

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