Telomerase and the process of cervical carcinogenesis

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
M NachajovaD Dvorska

Abstract

The integration of HPV infection in the epithelial cells is a key step in the induction of malignant changes of cervical cancer. In addition, there appear also other genomic alterations. Multi-step nature of carcinogenesis includes sequential accumulation of genetic changes that lead to invasive growth and progression. It is therefore necessary to understand the cervical carcinogenesis accompanied by chromosomal aberrations. The most common aberrations contain regions 5p15 and 3q26 coding the enzyme telomerase. For cervical cancer, telomerase is already active in case of precancerous lesions. Amplification of chromosomal region 3q26 detected by fluorescence in situ hybridization has the highest combined sensitivity and specificity in distinguishing low-grade lesion of high-grade lesions or invasive disease compared to the liquid-based cytology (LBC) and HPV DNA.

References

May 8, 2004·Genes & Development·Keren L Witkin, Kathleen Collins
Mar 29, 2005·The American Journal of Pathology·Kerstin Heselmeyer-HaddadThomas Ried
Jun 15, 2006·Nature Reviews. Drug Discovery·Jerry W Shay, Woodring E Wright
Jul 28, 2006·Cold Spring Harbor Symposia on Quantitative Biology·D A GallowayJ K McDougall
Aug 18, 2010·BMC Cancer·Frank A PolichtIrina A Sokolova
Feb 18, 2011·Journal of Cellular and Molecular Medicine·Jillian E KozielBrittney-Shea Herbert
May 29, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Alexandros RodolakisAris Antsaklis
Jan 31, 2014·Journal of Lower Genital Tract Disease·Veronika JanusicovaJan Danko
Sep 2, 2014·Acta Obstetricia Et Gynecologica Scandinavica·Erik KudelaJan Danko
Feb 11, 2015·American Journal of Obstetrics and Gynecology·Thomas C WrightMichael W Kilpatrick

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Citations

Jul 13, 2017·Viruses·Rachel Katzenellenbogen
May 18, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Rong LiuGuoxin Mao
May 29, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fernanda Costa Brandão BertiDanielle Malheiros

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