Abstract
Telomerase is a ribonucleoprotein that consists of a RNA component for synthesizing telomeric DNA repeats onto chromosome ends, so that telomere length can be maintained; telomerase activation in general signifies immortalization of cells. Because the telomerase activity of only a few cases of nonastrocytic gliomas and low-grade astrocytic gliomas have been examined before, telomerase activity from a broad spectrum of astrocytic and nonastrocytic gliomas were examined in this study. A total of 119 brain tumor samples, including 16 pilocytic astrocytomas, one dysembryoplastic neuroepithelial tumor (DNT), two pleomorphic xanthoastrocytomas (PXA), 15 ependymomas, 21 oligodendrogliomas, 13 grade II astrocytomas, 13 anaplastic astrocytomas, and 38 glioblastoma multiforme tumors (GBM), were studied, using a polymerase chain reaction (PCR)-based telomeric repeat amplification protocol assay. All pilocytic astrocytomas, DNT, PXA, and myxopapillary ependymomas were telomerase negative. Three of 13 (15.4%) classical ependymomas, 2 of 14 (14.3%) grade II oligodendrogliomas, and three of seven (42.9%) anaplastic oligodendrogliomas had detectable telomerase activity. The frequency of telomerase expression in ependymomas and oligodendrogliom...Continue Reading
Citations
Nov 7, 2000·Cancer·H J ChenC L Cho
Feb 19, 2002·Oncogene·Tadashi KomataSeiji Kondo
Oct 2, 2002·Journal of Surgical Oncology·Han-Jung ChenJui-Wei Lin
Jun 30, 2005·British Journal of Cancer·A YannopoulosM Talieri
Sep 18, 2008·British Journal of Cancer·U TaboriC Hawkins
Feb 7, 2020·Nature Communications·Lina SieverlingUNKNOWN PCAWG Consortium
Nov 6, 2012·Annual Review of Pathology·Fausto J RodriguezCharles G Eberhart
Feb 9, 2013·Neuro-oncology·Daniela LötschSabine Spiegl-Kreinecker
Mar 29, 2000·Neuropathology and Applied Neurobiology·E Di TomasoN M Hjelm
Jun 21, 2001·Journal of Neurosurgery·R PalliniL M Larocca
Nov 28, 2000·International Journal of Cancer. Journal International Du Cancer·M L FalchettiL M Larocca
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Roberto PalliniMaria Laura Falchetti
May 29, 2007·Cancer Investigation·Uri Tabori, Jeffrey S Dome
Jan 31, 2014·Journal of Neuro-oncology·Kathleen DorrisRachid Drissi
Apr 16, 2002·British Journal of Cancer·X-X TianH-K Ng
Oct 3, 2002·Cancer Letters·Takao FukushimaItaru Moro
Jul 15, 2021·Pathology Oncology Research : POR·Ornella FranzeseAntonio Ruggiero