Telomerase expression is differentially regulated in birds of differing life span

Annals of the New York Academy of Sciences
Mark F HaussmannCarol M Vleck

Abstract

Cellular senescence caused by telomere shortening has been suggested as one potential causal agent of aging. In some tissues, telomeres are maintained by telomerase; however, telomerase promotes tumor formation, suggesting a trade-off between aging and cancer. We predicted that telomerase activity should vary directly with life span. We determined telomerase activity in bone marrow in cross-sectional samples from two short-lived bird species and two long-lived bird species. The two short-lived species had high telomerase activity as hatchlings but showed a sharp downregulation in both the young and old adults, whereas the two long-lived species had relatively high telomerase activity in bone marrow that did not decrease with age. In zebra finches, the age-related change in telomerase activity varied in different tissues. Telomerase activity increased late in life in skeletal muscle, liver, and gonad, but not in blood or bone marrow.

References

Jan 1, 1994·Cold Spring Harbor Symposia on Quantitative Biology·C B HarleyC W Greider
Jan 6, 2001·Development, Growth & Differentiation·H A Taylor, M E Delany
Sep 11, 2003·Proceedings. Biological Sciences·Mark F HaussmannCarol M Vleck

❮ Previous
Next ❯

Citations

Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Britt J HeidingerPat Monaghan
Mar 24, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael B Bonsall
Dec 10, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Melissa Bateson
Jan 30, 2010·Ageing Research Reviews·Richard A MillerJames M Harper
May 17, 2006·Trends in Ecology & Evolution·Pat Monaghan, Mark F Haussmann
Dec 27, 2011·Ageing Research Reviews·Anthony J R HickeyAnthony R J Phillips
Oct 30, 2016·Experimental Gerontology·Jacob E SchmidtBritt J Heidinger
Mar 6, 2017·Biochemistry. Biokhimii︠a︡·D Y Travin, B A Feniouk
Mar 1, 2012·Aging·Pat Monaghan
Nov 18, 2020·Oecologia·Francois CriscuoloCarsten Schradin
Jun 4, 2021·Frontiers in Molecular Biosciences·Susanne HoltzeArne Sahm
Jun 19, 2021·The Journal of Experimental Biology·Jose C Noguera, Alberto Velando

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.