Telomerase inhibition by sulfoquinovosyldiacylglycerol from edible purple laver (Porphyra yezoensis)

Cancer Letters
Takahiro EitsukaTeruo Miyazawa

Abstract

As high telomerase activity is detected in most cancer cells, telomerase represents a promising cancer therapeutic target. We investigated the inhibitory effect of sulfoquinovosyldiacylglycerol (SQDG), distributed in plants and seaweeds, on human telomerase in a cell-free system. SQDG inhibited telomerase activity dose-dependently with 50% inhibition at 22 microM, whereas monogalactosyldiacylglycerol and digalactosyldiacylglycerol did not, even at concentrations of 100 microM. Moreover, we confirmed that eicosapentaenoic acid, one of the fatty acid components of SQDG, is a potent telomerase inhibitor with 50% inhibition at 19 microM. We speculate that the structure of the sulfate group and fatty acid of SQDG is important for the potent telomerase-inhibitory effect. Our findings suggest that SQDG has potential use as a therapeutic dietary compound for telomerase inhibition.

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Citations

Jul 26, 2012·Journal of Agricultural and Food Chemistry·Cheng-Jung Tsai, Bonnie Sun Pan
Nov 3, 2012·BMC Complementary and Alternative Medicine·Rahmat Ali KhanSumaira Sahreen
Oct 27, 2015·International Journal of Molecular Medicine·Hyun-Ah LeeTaek-Jeong Nam
Jun 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rahmat Ali KhanJasia Bokhari
Jan 3, 2009·Journal of Ethnopharmacology·Muhammad R KhanSaima Shaheen
Aug 1, 2006·Biochemical and Biophysical Research Communications·Takahiro EitsukaTeruo Miyazawa
Apr 19, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yvonne V YuanNatalie A Walsh
Feb 9, 2018·International Journal of Molecular Sciences·Takahiro EitsukaTeruo Miyazawa
Jan 18, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elisabete da CostaMaria R Domingues
Aug 22, 2018·Frontiers in Pharmacology·Celso AlvesRui Pedrosa
Aug 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diana LopesMaria Rosário Domingues
May 2, 2021·Natural Product Research·Okwuchukwu Kodichinma EbojiAbimbola Adepeju Sowemimo
Nov 23, 2017·Journal of Agricultural and Food Chemistry·Tomohiro BitoFumio Watanabe

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