Telomerase reverse transcriptase potentially promotes the progression of oral squamous cell carcinoma through induction of epithelial-mesenchymal transition

International Journal of Oncology
Tengda ZhaoQian Tao

Abstract

In recent years, researchers have found the critical role of telomerase in cellular transformation, proliferation, stemness and cell survival. High levels of telomerase reverse transcriptase (TERT) expression and telomerase activation have been reported in most cancer cells. Moreover, overexpression of human TERT (hTERT) is reported to be correlated with advanced invasive stage of the tumor progression and poor prognosis. Epithelial-mesenchymal transition (EMT), characterized by the loss of the cell-cell contact of epithelial cells and the acquisition of migratory and motile properties, is known to be a central mechanism responsible for invasiveness and metastasis of various cancers. Thus, we investigated whether hTERT plays a potential role in the development of EMT. As we expected, our clinical results showed that hTERT is overexpressed in oral epithelial dysplasia (OED) and OSCC tissues and correlates with clinical aggressiveness of oral squamous cell carcinoma (OSCC) patients. We then overexpressed hTERT in primary human oral epithelial cells (HOECS) and found that hTERT has the potential to prolong the lifespan, a process confering the characteristics of EMT by activating the Wnt/β-catenin pathway. Our findings provided an...Continue Reading

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Citations

Aug 10, 2016·Cancer Metastasis Reviews·Paolo Boscolo-RizzoAnita De Rossi
May 6, 2017·Journal of Chemical Theory and Computation·Barira IslamJiri Sponer
Dec 22, 2017·International Journal of Cancer. Journal International Du Cancer·Rong BuKhawla S Al-Kuraya
Oct 27, 2017·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Deepika Bablani PopliAman Chowdhry
May 4, 2018·Molecular Carcinogenesis·Rishi K JaiswalPramod K Yadava
Aug 18, 2018·International Journal of Molecular Sciences·Tomonori Sasahira, Tadaaki Kirita
Sep 7, 2019·Pathology Oncology Research : POR·Lizbeth Raju KShwetha Nambiar
Dec 25, 2019·Cold Spring Harbor Molecular Case Studies·Elisa MajounieJanessa Laskin

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