Telomere attrition and restoration in the normal teleost Oryzias latipes are linked to growth rate and telomerase activity at each life stage

Aging
Hitoshi HatakeyamaNaoshi Ishikawa

Abstract

Telomere shortening occurs when cells divide, both in vitro and in vivo. On the other hand, telomerase is able to maintain telomere length in cells by adding TTAGGG repeats to the ends of telomeres. However, the interrelationships existing among telomere length, telomerase activity and growth in vertebrates remain to be clarified. In the present study we measured telomere length (terminal restriction fragment length), telomerase activity and body growth of Oryzias latipes from the embryo stage until senescence. During the rapid growth stage (age 0-7 months), telomeres shortened in parallel with decreasing telomerase activity. Then, during adolescence (age 7 months - 1 year), telomeres lengthened quickly as growth slowed and telomerase activity increased. In the adult stage (age 1-4 years) characterized by little growth, telomerase activity decreased gradually and telomeres shortened. Our data indicate that telomere attrition and restoration are linked to growth and telomerase activity, and suggest that critical loss of telomere homeostasis is associated with mortality in this animal.

References

Mar 1, 1991·Mutation Research·C B Harley
Aug 1, 1990·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·C W Greider
Oct 1, 1971·Experimental Gerontology·N Egami
Jul 1, 1969·Experimental Gerontology·N Egami, H Etoh
Jan 1, 1994·Gerontology·H Dutta
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C W Greider
Feb 19, 1998·Experimental Gerontology·A D Woodhead
Sep 26, 2002·Annual Review of Anthropology·B Bogin
Jun 24, 2004·Mechanisms of Development·Takashi Iwamatsu
Jun 7, 2005·Trends in Biochemical Sciences·Peter M Lansdorp
Mar 10, 2009·Hormones : International Journal of Endocrinology and Metabolism·Elissa S Epel
Sep 24, 2010·Annals of the New York Academy of Sciences·Pat Monaghan
Mar 1, 2008·Molecular Ecology Resources·Mark F Haussmann, Robert A Mauck
Mar 21, 2013·Nature Communications·Lily DanialiAbraham Aviv
Aug 31, 2013·Cytogenetic and Genome Research·K Ocalewicz
Apr 3, 2015·Methods in Ecology and Evolution·Daniel H NusseyPat Monaghan

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Citations

Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mats OlssonChristopher Friesen
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Pat Monaghan, Susan E Ozanne
Oct 28, 2016·Molecular Ecology·Paul V DebesAnti Vasemägi
May 20, 2017·Journal of Evolutionary Biology·O VedderS Bouwhuis
Jan 18, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rachael V WilbournJelle J Boonekamp
Apr 11, 2018·The Journal of Experimental Biology·Darryl McLennanNeil B Metcalfe
Sep 24, 2020·Experimental Dermatology·Gaël RunelIngrid Masse
Jan 20, 2021·Biology Letters·Noëlie MolbertAurélie Goutte
Apr 29, 2021·Scientific Reports·Derek J SauerMark E Clark
Apr 1, 2021·The Journal of Experimental Biology·Christopher R FriesenMats Olsson
May 16, 2021·Ecotoxicology and Environmental Safety·Noëlie MolbertAurélie Goutte
May 12, 2021·Molecular Ecology·Darryl McLennanNeil B Metcalfe

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Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

Telemetric
SAS
R Foundation for Statistical Computing
R
ImageJ
LOWESS
Telometric

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