Telomere changes in human hepatocellular carcinomas and hepatitis virus infected noncancerous livers

Cancer
K OhashiY Konishi

Abstract

Telomeres, at the ends of eukaryotic chromosomes, are defined functionally as necessary for chromosome stability. Chromosome instability induced in part by loss of telomeric DNA has been considered to play a significant role in the development of human cancers. However, little is known about the status of telomeres per se during human hepatocellular carcinoma (HCC) development. The study was conducted to determine the length of terminal restriction fragments (TRFs) at the telomeric ends in 23 HCCs and 23 corresponding noncancerous liver tissues from the same patients harboring hepatitis virus infections, and in 5 samples of noncancerous livers without the hepatitis virus. The latter samples had been obtained as controls at surgery for metastatic liver tumors. All 23 HCCs demonstrated reduction in TRF length compared with the corresponding noncancerous liver tissues with viral infection. The TRF in the latter cases also demonstrated a significant shortening as compared with the virus free control tissue, the degree being calculated to represent an average of 42 cell divisions. Reduction in TRF length in HCC samples tended to increase with the tumor diameter, although this failed to show statistical significance. These results in...Continue Reading

References

May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A EguchiM Kojiro
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Jun 20, 1992·Journal of Molecular Biology·M Z LevyC B Harley
Apr 18, 1991·Nature·E H Blackburn
Mar 1, 1991·Mutation Research·C B Harley
Sep 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F HasanG Kuo
May 31, 1990·Nature·C B HarleyC W Greider
Aug 30, 1990·Nature·N D HastieR C Allshire
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R K MoyzisJ R Wu
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Dec 1, 1993·Environmental Health Perspectives·M B Kastan, S J Kuerbitz
Feb 1, 1994·Molecular and Cellular Biology·A J KlingelhutzJ K McDougall
Jul 1, 1993·Nature Genetics·P S MeltzerJ M Trent

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Citations

Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Senitiroh Hakomori
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Sen-itiroh Hakomori Si
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T MashimoK Watabe
Nov 24, 2004·Biochemical and Biophysical Research Communications·Tomoki NakajimaTakeshi Okanoue
Apr 25, 2000·Experimental Cell Research·H AikataT Ide
Feb 4, 2014·Seminars in Cancer Biology·Xinsong ChenMaria G Masucci
Jan 10, 2008·Journal of the National Cancer Institute·Marcia Bellon, Christophe Nicot
Sep 17, 1998·Japanese Journal of Cancer Research : Gann·T KanamaruH Hisatomi
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·O IsokawaH Asakura
Mar 5, 2005·Reproduction, Fertility, and Development·S Schaetzlein, K L Rudolph
Jun 30, 2019·Nature Reviews. Gastroenterology & Hepatology·Jean-Charles NaultJessica Zucman-Rossi
Oct 7, 2006·Current Opinion in Gastroenterology·J T Edwards, G A Macdonald
Jun 12, 2020·Seminars in Liver Disease·Daniel D Penrice, Douglas A Simonetto

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