journal cover

Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells

Stem Cell Research

Sep 4, 2019

Flavia S DonairesRodrigo T Calado

Abstract

Telomeropathies are a group of phenotypically heterogeneous diseases molecularly unified by pathogenic mutations in telomere-maintenance genes causing critically short telomeres. X-linked dyskeratosis congenita (DC), the prototypical telomere disease, manifested with ectodermal dysplasi...read more

Mentioned in this Paper

Study
DKC1
Pluripotent Stem Cells
Telomere Recombination
Bone Marrow
Cell Proliferation
Cell Differentiation Process
Cellular Reprogramming
Induced Pluripotent Stem Cells
Telomere
2
6
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Similar Papers Found In These Feeds

Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Telomeres in Cancer (Keystone)

Telomeres protect our genetic data and are found at the end of chromosomes. When a cell divides, telomeres become shorter. This process has been associated with the development of cancer. Here is the latest research on telomeres in cancer.

PSCs in Development and Disease

Pluripotent stem cells (PSCs) are progenitor cells that can give rise to three basic layers of the body, thus potentially allowing the production of any cells or tissues needed by the body for repair. Here is the latest research on the PSCs in development and disease.

Cancer Metabolic Reprogramming

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) may be obtained by direct reprogramming of different somatic cells to a pluripotent state by forced expression of a handful of transcription factors, These cells have similar properties to those of embryonic stem cells (escs) but bypass the ethical concerns of embryo destruction and can be exploited for both research and clinical applications.Discover the latest research on iPSC here.

Dpp4, Pluritpotency & Cancer Cells

DPP4 has the potential to truncate proteins. DPP4-mediated truncation of certain chemokines, interleukins, and colony stimulating factors have recently been linked to regulation of hematopoietic stem/progenitor cells. Given its role in tumor biology, it is also used as a marker for various cancers. Here is the latest research.

Spatial & Lineage Atlas of Bone Marrow Hematopoiesis

Mapping bone marrow hematopoiesis by combining transcriptomics and imaging techniques will facilitate the study of hematopoietic disease and the development of novel therapeutics. This feed includes new research on analysis of the bone marrow hematopoiesis by multiple approaches.

Genetic Engineering to Program Cells

Genetic engineering is a process that alters the genetic structure of an organism by removing or introducing DNA. This technique is being tested to program cells. Discover the latest research on genetic engineering to program cells here.

Telomeres in Cancer

Telomeres protect our genetic data and are found at the end of chromosomes. When a cell divides, telomeres become shorter. This process has been associated with the development of cancer. Here is the latest research on telomeres in cancer.

Hereditary Cancer Syndromes

Hereditary cancer syndromes comprise 5% of all cancers and have an increased risk of early onset and of multiple or bilateral malignancies. Here is the latest research on hereditary cancer syndromes.

iPSC Derived Cell Therapies for Cancer

Cell therapies derived from induced Pluripotent Stem Cell (iPSC) technology is emerging in cancer therapeutics. For example, iPSCs allow the development of immune therapies and drug screening programs in the genetic background of the patient. Discover the latest research on iPSC derived cell therapies for cancer here.

Cancer Metabolic Reprogramming (Keystone)

Cancer metabolic reprogramming is important for the rapid growth and proliferation of cancer cells. Cancer cells have the ability to change their metabolic demands depending on their environment, regulated by the activation of oncogenes or loss of tumor suppressor genes. Here is the latest research on cancer metabolic reprogramming.

Gene Regulation, Differentiation & Reprogramming (Keystone)

This feed focuses on alterations of gene regulation during cell differentation and reprogramming processes. Here is the latest research on gene regulation in differentiation and reprogramming processes.

Related Papers

© 2020 Meta ULC. All rights reserved

Telomere dynamics and hematopoietic differentiation of human DKC1-mutant induced pluripotent stem cells

Stem Cell Research

Sep 4, 2019

Flavia S DonairesRodrigo T Calado

PMID: 31479877

DOI: 10.1016/j.scr.2019.101540

Abstract

Telomeropathies are a group of phenotypically heterogeneous diseases molecularly unified by pathogenic mutations in telomere-maintenance genes causing critically short telomeres. X-linked dyskeratosis congenita (DC), the prototypical telomere disease, manifested with ectodermal dysplasi...read more

Mentioned in this Paper

Study
DKC1
Pluripotent Stem Cells
Telomere Recombination
Bone Marrow
Cell Proliferation
Cell Differentiation Process
Cellular Reprogramming
Induced Pluripotent Stem Cells
Telomere
2
6

Similar Papers Found In These Feeds

Telomere Dysfunction

Telomere dysfunction in response to critical telomere shortening induces dna damage checkpoints that lead to cell cycle arrest and/or cell death.

Telomeres in Cancer (Keystone)

Telomeres protect our genetic data and are found at the end of chromosomes. When a cell divides, telomeres become shorter. This process has been associated with the development of cancer. Here is the latest research on telomeres in cancer.

Related Papers

The Journal of Clinical Investigation

Defective telomere elongation and hematopoiesis from telomerase-mutant aplastic anemia iPSCs

The Journal of Clinical InvestigationApril 16, 2013
Thomas WinklerRodrigo T Calado
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
/papers/telomere-dynamics-and-hematopoietic/31479877