Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia

American Journal of Obstetrics and Gynecology
Rivka Sukenik-HalevyTal Biron-Shental

Abstract

Telomeres are nucleoprotein structures, essential for chromosome stability and cell survival. Telomeres are progressively shortened with each cell division and by environmental factors. Telomere loss has been linked to age and stress-induced premature senescence. Dysfunctional telomeres tend to form aggregates, which consist of the end-to-end fusion of telomeres. Telomere elongation is carried out by telomerase, which is a specific reverse transcriptase capable of adding telomeric repeats to chromosome termini. The TERC gene encodes the RNA template of the telomerase. Another compensatory mechanism that is enhanced in response to telomere shortening and senescence is the telomere capture (TC). Telomere shortening and elevated aggregate formation have been observed in trophoblasts from pregnancies complicated with preeclampsia (PE). We opted to study mechanisms of telomere shortening in trophoblasts from pregnancies complicated with PE and to assess telomere length and homeostasis in fetal cord blood cells from PE pregnancies. Placental specimens and cord blood samples from uncomplicated pregnancies and from pregnancies complicated with PE were collected. Staining with 4',6-diamidino-2-phenylindole was used to assess nuclear fra...Continue Reading

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Citations

Feb 28, 2017·American Journal of Reproductive Immunology : AJRI·Zakia SultanaRoger Smith
Jan 31, 2017·Placenta·Lynne S Cox, Christopher Redman
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Oct 10, 2018·Reproductive Sciences·Luis Alejandro Arias-Sosa
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