Telomere length and survival in primary cutaneous melanoma patients

Scientific Reports
Sivaramakrishna RachakondaRajiv Kumar

Abstract

Telomere repeats at chromosomal ends, critical to genomic integrity, undergo age-dependent attrition. Telomere length, a polygenic trait, has been associated with risk of several disorders including cancers. In contrast to association of long telomeres with increased risk of several cancers, including melanoma, emerging reports suggest that short telomeres predict poor survival in patients with different cancers. In this study based on 1019 stage I and II cutaneous melanoma patients, we show an association between the patients with short telomeres and poor melanoma-specific survival (HR 2.05, 95% CI 1.33-3.16) compared to patients with long telomeres. Due to inverse correlation between age and telomere length (r -0.19, P < 0.0001), we stratified the patients into quantiles based on age at diagnosis and also carried out age-matched analysis. The effect of short telomeres on survival was determined by using multivariate Cox regression that included composite genetic risk score computed from genotyping of the patients for telomere-length associated polymorphisms. The effect of decreased telomere length on poor melanoma-specific survival was particularly strong in patients within the age quantile below 30 years (HR 3.82, 95% CI 1.1...Continue Reading

References

Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Elissa S EpelRichard M Cawthon
Jul 14, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Veronique BatailleTim D Spector
Feb 9, 2010·Nature Genetics·Veryan CoddNilesh J Samani
Apr 22, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Min ShenQing Lan
May 9, 2012·Annals of Surgery·Florentien E M In 't HoutRichard A Scolyer
May 26, 2012·Current Opinion in Immunology·Nan-ping Weng
Jul 24, 2012·Cell·Eran HodisLynda Chin
Jan 10, 2013·Nature Reviews. Molecular Cell Biology·Jayakrishnan Nandakumar, Thomas R Cech
Jan 26, 2013·Science·Susanne HornRajiv Kumar
Mar 8, 2013·Journal of the National Cancer Institute·Maren WeischerStig E Bojesen
Jul 11, 2013·Annals of Surgical Oncology·Charles M BalchVernon K Sondak
Aug 7, 2013·Journal of the National Cancer Institute·Laureline RogerDuncan M Baird
Aug 16, 2013·Nature·Ludmil B AlexandrovMichael R Stratton
Sep 24, 2013·Lancet·Alexander M M EggermontCaroline Robert
Sep 28, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Philip J Mason, Nieves Perdigones
Oct 11, 2013·Pigment Cell & Melanoma Research·Russell R BraeuerMenashe Bar-Eli
Feb 27, 2014·Nature Communications·Barbara HeidenreichRajiv Kumar
Mar 15, 2014·Journal of the National Cancer Institute·Catherine DugganAnne McTiernan
Sep 14, 2014·Journal of the National Cancer Institute·Klaus G GriewankDirk Schadendorf
Sep 19, 2014·Journal of the National Cancer Institute·Mark M IlesUNKNOWN GenoMEL Consortium
Jan 28, 2015·Journal of Medical Genetics·Massimo ManginoAbraham Aviv
Feb 11, 2015·JAMA : the Journal of the American Medical Association·Shahinaz M GadallaSharon A Savage
Mar 15, 2015·Journal of Medical Genetics·Jacob B HjelmborgAbraham Aviv
Mar 27, 2015·International Journal of Cancer. Journal International Du Cancer·Simone RiberoVeronique Bataille
Mar 27, 2015·International Journal of Cancer. Journal International Du Cancer·Ismail HosenRajiv Kumar
Jun 16, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jinghong DaiLong Yi
Jun 20, 2015·Cell·UNKNOWN Cancer Genome Atlas Network
Sep 5, 2015·Journal of Medical Genetics·Jazlyn ReadNicholas K Hayward
Feb 15, 2016·International Journal of Cancer. Journal International Du Cancer·Eduardo NagoreRajiv Kumar
Jun 9, 2016·JAMA Dermatology·Jon D EmeryFiona M Walter
Aug 9, 2016·International Journal of Epidemiology·Line RodeStig E Bojesen
Nov 8, 2016·Nature Structural & Molecular Biology·Elise FouquerelPatricia L Opresko
Jan 18, 2017·Nature Reviews. Molecular Cell Biology·John Maciejowski, Titia de Lange
Jan 31, 2017·Nature Genetics·Floris P BarthelRoel G W Verhaak

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Methods Mentioned

BETA
biopsy
PCR

Software Mentioned

SAS

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