Mar 16, 2019

Telomere length, arsenic exposure and risk of basal cell carcinoma of skin

Carcinogenesis
Nalini SrinivasRajiv Kumar

Abstract

Telomere length per se a heritable trait has been reported to be associated with different diseases including cancers. In this study, based on arsenic-exposed 528 cases with basal cell carcinoma (BCC) of skin and 533 healthy controls, we investigated effect of telomere length, measured by real-time PCR, on the disease risk. We observed a statistically significant association between decreased telomere length and increased BCC risk [odds ratio (OR) = 5.92, 95% confidence interval (CI) = 3.92 to 9.01, P < 0.0001]. Due to confounder effect of arsenic exposure, in a two-sample Mendelian randomization (MR), telomere length associated single-nucleotide polymorphisms as instrument variables violated valid assumptions; however, one-sample MR adjusted for arsenic exposure indicated an increased risk of BCC with short telomeres. The interaction between arsenic exposure and telomere length on BCC risk was statistically significant (P = 0.02). Within each tertile based on arsenic exposure, the individuals with shorter telomeres were at an increased risk of BCC, with highest risk being in the highest exposed group (OR = 16.13, 95% CI = 6.71 to 40.00, P < 0.0001), followed by those in medium exposure group and low exposure group. The combine...Continue Reading

  • References51
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References

  • References51
  • Citations2

Citations

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Study
Drug Carriers
Mendelian Randomization Analysis
Magnetic Resonance Imaging
Arsenic
Telomere
Instrument - Device
Malignant Neoplasms
Single Nucleotide Polymorphism

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