Telomere length in Parkinson's disease: A meta-analysis

Experimental Gerontology
Diego A ForeroGeorge Perry

Abstract

Parkinson's disease (PD) is a common and severe movement disorder. Differences in telomere length (TL) have been reported as possible risk factors for several neuropsychiatric disorders, including PD. Results from published studies for TL in PD are inconsistent, highlighting the need for a meta-analysis. In the current work, a meta-analysis of published studies for TL in PD was carried out. PubMed, Web of Science and Google Scholar databases were used to identify relevant articles that reported TL in groups of PD patients and controls. A random-effects model was used for meta-analytical procedures. The meta-analysis included eight primary studies, derived from populations of European and Asian descent, and did not show a significant difference in TL between 956 PD patients and 1284 controls (p value: 0.246). Our results show that there is no consistent evidence of shorter telomeres in PD patients and suggest the importance of future studies on TL and PD that analyze other populations and also include assessment of TL from different brain regions.

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Citations

Sep 7, 2016·Genes·Vasileios KordinasStylianos Chatzipanagiotou
Apr 12, 2017·EBioMedicine·Juulia JylhäväSara Hägg
Feb 20, 2018·The Journal of Clinical Investigation·Darren J Baker, Ronald C Petersen
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Aug 8, 2020·Frontiers in Cellular Neuroscience·Tina LevstekKatarina Trebušak Podkrajšek
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Sep 1, 2017·Biomarkers in Medicine·Ismail ThanseemAyyappan Anitha
Dec 24, 2019·Journal of Parkinson's Disease·Carmen Martin-RuizGabriele Saretzki
Dec 15, 2020·Mechanisms of Ageing and Development·Melanie EnglerIon Cristian Cirstea
Feb 6, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zizhen SiXidi Wang
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Jul 17, 2020·International Journal of Biological Macromolecules·Jiequan WangXinhua Liu
Nov 6, 2018·Journal of the Neurological Sciences·Daniela ScarabinoRosa Maria Corbo
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Aug 10, 2021·Multiple Sclerosis and Related Disorders·Annalise E Miner, Jennifer S Graves
Oct 15, 2021·Journal of Neuroinflammation·Antonina KouliCaroline H Williams-Gray

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