Telomere length in the colon declines with age: a relation to colorectal cancer?

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Jacintha N O'SullivanPeter S Rabinovitch

Abstract

Telomeres shorten with age, which may be linked to genomic instability and an increased risk of cancer. To explore this association, we analyzed telomere length in normal colorectal tissue of individuals at different ages using quantitative-fluorescence in situ hybridization (Q-FISH) and quantitative-PCR (Q-PCR). Using Q-FISH, we also examined the histologically normal epithelium adjacent to, or distant from, colon adenomas and cancers, in addition to the neoplasms. Q-FISH and Q-PCR showed that telomere length was inversely associated with age until approximately ages 60 to 70; surprisingly, beyond this age, telomere length was positively associated with age. This association was found exclusively in epithelial, and not in stromal, cells. Peripheral blood lymphocytes showed an inverse association between telomere length and age, but without any apparent increase in telomere length in the oldest individuals. Telomere length in larger adenoma lesions (>2 cm) was significantly shorter than in normal adjacent (P = 0.004) or normal distant (P = 0.05) tissue from the same individuals. However, telomere length in histologically normal epithelium adjacent to cancers or in adenomas <2 cm was not statistically different from that of the ...Continue Reading

References

Apr 18, 1991·Nature·E H Blackburn
Mar 1, 1991·Mutation Research·C B Harley
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·E Chang, C B Harley
Jan 29, 2000·Statistics in Medicine·H J KimD N Midthune
Jul 13, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Meyerson
Feb 7, 2002·Experimental Gerontology·Kaiyo TakuboKen-Ichi Nakamura
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Oct 2, 2002·Nature Genetics·Jacintha N O'SullivanPeter S Rabinovitch
Nov 26, 2002·The Journal of Investigative Dermatology·Ken-Ichi NakamuraKaiyo Takubo
Mar 22, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Scott BrouiletteNilesh J Samani
Aug 21, 2003·Journal of the National Cancer Institute·Xifeng WuMargaret R Spitz
Oct 16, 2003·European Journal of Gastroenterology & Hepatology·Wendy L CraigMark A Vickers
Feb 21, 2004·Lancet·Tim S NawrotAbraham Aviv
Apr 2, 2004·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jacintha N O'SullivanPeter S Rabinovitch
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ralf GertlerJoerg-Ruediger Siewert
Jul 13, 2004·Annals of the New York Academy of Sciences·Duncan M Baird, David Kipling
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ylva StewéniusDavid Gisselsson

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Citations

Apr 8, 2010·Medical Oncology·Majid KheirollahiParvin Mehdipour
Aug 8, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Robert Y L ZeeJulie E Buring
Dec 8, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·I-Min LeeRobert Y L Zee
Jul 30, 2011·World Journal of Gastroenterology : WJG·Ferenc SiposZsolt Tulassay
Feb 6, 2014·Genetic Testing and Molecular Biomarkers·Mahdi Montazer HaghighiRamin Radpour
May 17, 2014·Cellular and Molecular Life Sciences : CMLS·Sebastian Foersch, Markus F Neurath
Mar 13, 2014·World Journal of Gastroenterology : WJG·Roberta BertorelleAnita De Rossi
Oct 29, 2013·Expert Review of Gastroenterology & Hepatology·Nivedita BasuLisa A Boardman
Apr 16, 2015·Journal of Surgical Oncology·Cristina Valls-BautistaJoan Viñas-Salas
Oct 4, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nathan J O'CallaghanMichael A Conlon
Oct 27, 2015·Genetic Testing and Molecular Biomarkers·Ayse Tarbin JannuzziGül Özhan
Dec 7, 2007·Mechanisms of Ageing and Development·Dennis Kappei, J Arturo Londoño-Vallejo
Aug 31, 2007·Biochimie·J Arturo Londoño-Vallejo
Aug 5, 2015·Prostate Cancer and Prostatic Diseases·C GuD Ye
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Manas KotepuiLek Charoenkijkajorn
Apr 25, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Tong-Bao FengChun-Jian Qi
Oct 22, 2011·Mechanisms of Ageing and Development·Laura C GreavesDouglass M Turnbull
Apr 5, 2015·Digestive Diseases and Sciences·Masakazu Yashiro
Aug 30, 2017·International Journal of Molecular Sciences·Eric Le Balc'hMichel Charbonneau
Oct 18, 2018·PloS One·Sarah D PeacockWill D King
Dec 21, 2018·Critical Reviews in Toxicology·Peter MøllerMartin Roursgaard
Nov 23, 2006·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anna GenescàLaura Tusell
Jul 20, 2016·World Journal of Gastroenterology : WJG·Parisa Aghagolzadeh, Ramin Radpour

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