Telomere length was similar in school-age children with bronchopulmonary dysplasia and allergic asthma

Acta Paediatrica
E HenckelK Bohlin

Abstract

Inflammation is a major factor in the pathophysiology of bronchopulmonary dysplasia (BPD), and it contributes to accelerated telomere shortening and cellular ageing. This study aimed to determine its effect on telomere length and lung function in school-aged children born preterm with BPD. We examined 29 children with BPD, born preterm in Stockholm county 1998-99, along with 28 children with allergic asthma born at term matched for age and gender. At 10 years of age, we measured relative telomere length (RTL) in blood by quantitative polymerase chain reaction, lung function by spirometry and inflammation by fractional exhaled nitric oxide and blood cytokines. RTL was not different in preterm born with BPD compared to term born children with asthma. The gender effect was strong in both groups; girls had significantly longer median RTL than boys (1.8 versus 1.5, p < 0.01). Short RTL was associated with low forced expiratory flow, also after adjusting for gender, but was not affected by severity of BPD or ongoing inflammation. Telomere length was similar in 10-year-old children born preterm with a history of BPD and term born children with allergic asthma. However, impaired lung function and male gender were associated with short ...Continue Reading

References

Apr 18, 1991·Nature·E H Blackburn
Feb 7, 2001·Pediatric Research·U FriedrichU Klotz
Jun 13, 2001·American Journal of Respiratory and Critical Care Medicine·A H Jobe, E Bancalari
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Aug 24, 2002·Pediatric Research·Koji OkudaAbraham Aviv
Oct 13, 2004·American Journal of Respiratory and Critical Care Medicine·Eugenio BaraldiMarco Filippone
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Feb 21, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·A AkkadB Williams
Dec 11, 2008·Diabetes·Magnus KaijserAnders Ekbom
Apr 10, 2010·American Journal of Respiratory and Critical Care Medicine·Joseph FawkeJanet Stocks
Sep 22, 2011·JAMA : the Journal of the American Medical Association·Casey CrumpMarilyn A Winkleby
Mar 13, 2012·The European Respiratory Journal·Marco FilipponeEugenio Baraldi
Aug 7, 2012·The Journal of Pediatrics·Norbert TeigEckard Hamelmann
Jun 12, 2013·Thorax·Maria VollsæterThomas Halvorsen
Dec 7, 2013·The European Respiratory Journal·Eva AlbrechtHolger Schulz
Jun 24, 2014·American Journal of Respiratory and Critical Care Medicine·Daniel W BelskyAvshalom Caspi
Oct 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Sonja EntringerPathik D Wadhwa
Oct 29, 2014·Pediatrics·Idan ShalevTerrie E Moffitt
Feb 15, 2015·The Journal of Pediatrics·Stacy S DruryKatherine P Theall
Dec 1, 2015·PloS One·Carolina C J SmeetsAnita C S Hokken-Koelega
Jun 22, 2017·Pediatric Pulmonology·Björn NordlundEva B Broström

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Citations

Mar 3, 2020·Frontiers in Cell and Developmental Biology·Zhao-Ni WangZhuang-Gui Chen
Jan 24, 2019·Cells·Kara J TurnerDarren K Griffin
Dec 11, 2019·Therapeutic Advances in Respiratory Disease·Sharon A McGrath-Morrow, Joseph M Collaco

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