PMID: 9539717May 16, 1998Paper

Telomere loss in cells treated with cisplatin

Proceedings of the National Academy of Sciences of the United States of America
T Ishibashi, S J Lippard

Abstract

Telomeres play an important role in the immortalization of proliferating cells. The long tandem repeats of 5'-TTAGGG-3' sequences in human telomeres are potential targets for the anticancer drug cisplatin, which forms mainly intrastrand d(GpG) and d(ApG) cross-links on DNA. The present study reveals that telomeres in cisplatin-treated HeLa cells are markedly shortened and degraded. A dose that killed 61% of the cells but allowed one round of cell division resulted in shortened telomeres before the induction of apoptosis. Higher doses of cisplatin halted cell cycle progression during the first S phase and triggered apoptosis followed by degradation of telomere repeats. A model in which both cell division with incomplete replication and induction of apoptosis by cisplatin could occur was devised to explain the drug-induced telomere loss.

References

Sep 1, 1978·Mutation Research·E Gebhart, H Kappauf
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Jun 20, 1992·Journal of Molecular Biology·M Z LevyC B Harley
Jul 2, 1992·Nature·D P Lane
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M ScheffnerP M Howley
Apr 18, 1991·Nature·E H Blackburn
Mar 1, 1991·Mutation Research·C B Harley
May 31, 1990·Nature·C B HarleyC W Greider
Jan 1, 1989·Annual Review of Genetics·V A Zakian
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J MeyneR K Moyzis
Jan 1, 1989·Molecular and Cellular Biology·E R Henderson, E H Blackburn
Aug 12, 1988·Cell·R M McCarroll, W L Fangman
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R K MoyzisJ R Wu
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A L Pinto, S J Lippard
Sep 1, 1995·Science·J FengJ Yu
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·P A KrukV A Bohr
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·T de Lange
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·C M CounterC B Harley
Jun 20, 1996·Nature·T Jacks, R A Weinberg
Aug 6, 1996·Biochemistry·D B ZambleS J Lippard
Oct 1, 1996·Mutation Research·C M Counter
Jan 3, 1997·Biochemical and Biophysical Research Communications·F Ishikawa
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J W Shay, S Bacchetti

❮ Previous
Next ❯

Citations

Nov 13, 2008·Cytotechnology·Lionel GuittatJean-Louis Mergny
May 31, 2007·Investigational New Drugs·Sandra MuellerCarsten Bokemeyer
Oct 26, 2000·European Journal of Pharmacology·M VietorM Weller
Aug 19, 2003·European Journal of Pharmacology·Yan ZhangJing-Fen Qin
Feb 16, 2000·Journal of Dermatological Science·M MatsuiA Aioi
May 9, 2000·Critical Reviews in Oncology/hematology·F LavelleP Mailliet
Jun 13, 2009·Natural Product Research·Yunshan YangMalin Li
Aug 22, 2007·Rejuvenation Research·Gesche TallenKarl Riabowol
Oct 19, 2000·Anti-cancer Drugs·L R Kelland
Jul 31, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Chiara Mondello, A Ivana Scovassi
Jan 24, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathryn L TerryDaniel W Cramer
Jun 3, 2009·The Journal of Clinical Investigation·Waleed M AbuzeidDaqing Li
Jun 18, 2002·The Lancet Oncology·Alexander D GuminskiAnna deFazio
Mar 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eiichi KimuraTohru Koike
Jan 5, 2001·Expert Opinion on Investigational Drugs·P J Perry, T C Jenkins
Nov 14, 1998·Annals of Medicine·V UrquidiS Goodison
Aug 14, 2009·The Journal of Investigative Dermatology. Symposium Proceedings·Barbara A GilchrestMina Yaar
Sep 27, 2000·Neoplasia : an International Journal for Oncology Research·A S MultaniS Pathak
Nov 26, 2002·The Journal of Investigative Dermatology·Ken-Ichi NakamuraKaiyo Takubo
Jul 3, 2007·British Journal of Pharmacology·P Phatak, A M Burger
Jan 10, 2012·Journal of Mass Spectrometry : JMS·Silvan R StuckiStefan Schürch
Jul 10, 2004·Experimental Cell Research·Miguel A RubioJudith Campisi
Jul 29, 2008·Biochemical Pharmacology·David A GewirtzLynne W Elmore
Jun 25, 2015·Carcinogenesis·Sabine A S LangieAndrew R Collins
May 5, 1999·Current Opinion in Chemical Biology·J Reedijk
Feb 10, 2000·Experimental Cell Research·K IshiiK V Chin
Feb 24, 2009·Biochimica Et Biophysica Acta·R Patel, A Shervington

❮ Previous
Next ❯

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